{"id":534,"title":"Succinate dehydrogenase (SDH) inhibition leads to oxidative stress","short_name":"SDH inhibition, oxidative stress","created_at":"2024-05-28T18:52:55.000-04:00","updated_at":"2026-04-11T04:19:07.000-04:00","corresponding_author":{"id":16786,"created_at":"2023-03-31T16:57:39.000-04:00","updated_at":"2026-08-13T10:32:16.000-04:00","subscribed":true,"novice":true},"aop_stressors":[{"stressor_id":774,"stressor_name":"Boscalid"},{"stressor_id":775,"stressor_name":"Bixafen"},{"stressor_id":776,"stressor_name":"Sedaxane"}],"aop_mies":[{"event_id":2118,"event":"Succinate dehydrogenase, inhibited","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":1446,"event":"Decrease, Coupling of oxidative phosphorylation","event_type":"KeyEvent"},{"event_id":1115,"event":"Increase, Reactive oxygen species","event_type":"KeyEvent"}],"aop_aos":[{"event_id":1392,"event":"Increase, Oxidative Stress ","event_type":"AdverseOutcome"}],"relationships":[{"relation":3880,"upstream_event_id":2118,"upstream_event":"Succinate dehydrogenase, inhibited","downstream_event_id":1446,"downstream_event":"Decrease, Coupling of oxidative phosphorylation"},{"relation":4324,"upstream_event_id":1446,"upstream_event":"Decrease, Coupling of oxidative phosphorylation","downstream_event_id":1115,"downstream_event":"Increase, Reactive oxygen species"},{"relation":4325,"upstream_event_id":1115,"upstream_event":"Increase, Reactive oxygen species","downstream_event_id":1392,"downstream_event":"Increase, Oxidative Stress "}]}