{"id":549,"title":"Aromatase inhibition leads to reproductive toxicity (including growth and developmental toxicity) in adult female zebrafish","short_name":"Aromatase inhibition leads to reproductive toxicity","created_at":"2024-11-16T04:53:58.000-05:00","updated_at":"2024-11-19T03:22:36.000-05:00","corresponding_author":{"id":16708,"created_at":"2023-03-27T03:40:01.000-04:00","updated_at":"2025-04-17T04:42:28.000-04:00","subscribed":true,"novice":true},"aop_stressors":[],"aop_mies":[{"event_id":36,"event":"Inhibition, Aromatase","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":2277,"event":"Inhibition, aromatase activity in plasma","event_type":"KeyEvent"},{"event_id":219,"event":"Reduction, Plasma 17beta-estradiol concentrations","event_type":"KeyEvent"},{"event_id":221,"event":"Reduction, Plasma vitellogenin concentrations","event_type":"KeyEvent"},{"event_id":309,"event":"Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development","event_type":"KeyEvent"}],"aop_aos":[{"event_id":1467,"event":"Growth, reduction","event_type":"AdverseOutcome"},{"event_id":78,"event":"Reduction, Cumulative fecundity and spawning","event_type":"AdverseOutcome"},{"event_id":442,"event":"Decreased, Population trajectory","event_type":"AdverseOutcome"}],"relationships":[{"relation":4123,"upstream_event_id":36,"upstream_event":"Inhibition, Aromatase","downstream_event_id":2277,"downstream_event":"Inhibition, aromatase activity in plasma"},{"relation":4124,"upstream_event_id":2277,"upstream_event":"Inhibition, aromatase activity in plasma","downstream_event_id":219,"downstream_event":"Reduction, Plasma 17beta-estradiol concentrations"},{"relation":4125,"upstream_event_id":219,"upstream_event":"Reduction, Plasma 17beta-estradiol concentrations","downstream_event_id":221,"downstream_event":"Reduction, Plasma vitellogenin concentrations"},{"relation":4126,"upstream_event_id":221,"upstream_event":"Reduction, Plasma vitellogenin concentrations","downstream_event_id":309,"downstream_event":"Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development"},{"relation":4127,"upstream_event_id":309,"upstream_event":"Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development","downstream_event_id":78,"downstream_event":"Reduction, Cumulative fecundity and spawning"},{"relation":4128,"upstream_event_id":309,"upstream_event":"Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development","downstream_event_id":1467,"downstream_event":"Growth, reduction"},{"relation":4129,"upstream_event_id":78,"upstream_event":"Reduction, Cumulative fecundity and spawning","downstream_event_id":442,"downstream_event":"Decreased, Population trajectory"}]}