{"id":556,"title":"Decreased Na/K ATPase activity leading to heart failure","short_name":"Inhibition of the sodium-potassium-ATP pump ","created_at":"2024-11-19T12:36:38.000-05:00","updated_at":"2024-12-03T09:28:07.000-05:00","corresponding_author":{"id":859,"created_at":"2019-04-12T16:01:11.000-04:00","updated_at":"2026-01-19T09:09:00.000-05:00","subscribed":true,"novice":true},"aop_stressors":[{"stressor_id":804,"stressor_name":"Digoxin"},{"stressor_id":805,"stressor_name":"Ouabain"},{"stressor_id":59,"stressor_name":"Lead"},{"stressor_id":36,"stressor_name":"Mercury"},{"stressor_id":250,"stressor_name":"Polycyclic aromatic hydrocarbons (PAHs)"},{"stressor_id":43,"stressor_name":"Organophosphates"},{"stressor_id":806,"stressor_name":"Thapsigargin"},{"stressor_id":803,"stressor_name":"E-4031"}],"aop_mies":[{"event_id":1562,"event":"Decreased Na/K ATPase activity","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":1321,"event":"Increased, intracellular sodium (Na+)","event_type":"KeyEvent"},{"event_id":2287,"event":"Impaired Sodium-Calcium Exchange","event_type":"KeyEvent"},{"event_id":389,"event":"Increased, Intracellular Calcium overload","event_type":"KeyEvent"},{"event_id":1532,"event":"Decrease, Cardiac contractility ","event_type":"KeyEvent"}],"aop_aos":[{"event_id":1535,"event":"Heart failure ","event_type":"AdverseOutcome"}],"relationships":[{"relation":4161,"upstream_event_id":1321,"upstream_event":"Increased, intracellular sodium (Na+)","downstream_event_id":2287,"downstream_event":"Impaired Sodium-Calcium Exchange"},{"relation":4162,"upstream_event_id":2287,"upstream_event":"Impaired Sodium-Calcium Exchange","downstream_event_id":389,"downstream_event":"Increased, Intracellular Calcium overload"},{"relation":4163,"upstream_event_id":389,"upstream_event":"Increased, Intracellular Calcium overload","downstream_event_id":1532,"downstream_event":"Decrease, Cardiac contractility "},{"relation":4164,"upstream_event_id":1532,"upstream_event":"Decrease, Cardiac contractility ","downstream_event_id":1535,"downstream_event":"Heart failure "},{"relation":4194,"upstream_event_id":1562,"upstream_event":"Decreased Na/K ATPase activity","downstream_event_id":1321,"downstream_event":"Increased, intracellular sodium (Na+)"}]}