{"id":559,"title":"Inhibition of acetylcholinesterase (AChE) leading to arrhythmias","short_name":"Inhibition of acetylcholinesterase (AChE),  arrhythmias","created_at":"2024-11-19T12:52:25.000-05:00","updated_at":"2024-12-03T09:29:15.000-05:00","corresponding_author":{"id":859,"created_at":"2019-04-12T16:01:11.000-04:00","updated_at":"2026-04-14T04:49:44.000-04:00","subscribed":true,"novice":true},"aop_stressors":[{"stressor_id":813,"stressor_name":"Donepezil"},{"stressor_id":814,"stressor_name":"Neostigmine"},{"stressor_id":815,"stressor_name":"Pyridostigmine"},{"stressor_id":45,"stressor_name":"Parathion"},{"stressor_id":546,"stressor_name":"Malathion"},{"stressor_id":280,"stressor_name":"Chlorpyrifos"},{"stressor_id":816,"stressor_name":"Diazinon"},{"stressor_id":817,"stressor_name":"Sarin"},{"stressor_id":818,"stressor_name":"Tabun"},{"stressor_id":819,"stressor_name":"Carbaryl"},{"stressor_id":820,"stressor_name":"Aldicarb"},{"stressor_id":821,"stressor_name":"Physostigmine"},{"stressor_id":391,"stressor_name":"Ciprofloxacin"},{"stressor_id":822,"stressor_name":"Carbofuran"},{"stressor_id":823,"stressor_name":"Pilocarpine"},{"stressor_id":824,"stressor_name":"Bethanechol"}],"aop_mies":[{"event_id":12,"event":"Acetylcholinesterase (AchE) Inhibition","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":1602,"event":"Increased Muscarinic Acetylcholine Receptors","event_type":"KeyEvent"},{"event_id":698,"event":"Altered, Action Potential","event_type":"KeyEvent"},{"event_id":2280,"event":"Increased delay in heart electrical conduction","event_type":"KeyEvent"}],"aop_aos":[{"event_id":1106,"event":"Occurrence, cardiac arrhythmia","event_type":"AdverseOutcome"}],"relationships":[{"relation":4170,"upstream_event_id":12,"upstream_event":"Acetylcholinesterase (AchE) Inhibition","downstream_event_id":1602,"downstream_event":"Increased Muscarinic Acetylcholine Receptors"},{"relation":4171,"upstream_event_id":1602,"upstream_event":"Increased Muscarinic Acetylcholine Receptors","downstream_event_id":698,"downstream_event":"Altered, Action Potential"},{"relation":4172,"upstream_event_id":698,"upstream_event":"Altered, Action Potential","downstream_event_id":2280,"downstream_event":"Increased delay in heart electrical conduction"},{"relation":4173,"upstream_event_id":2280,"upstream_event":"Increased delay in heart electrical conduction","downstream_event_id":1106,"downstream_event":"Occurrence, cardiac arrhythmia"}]}