{"id":561,"title":"Aromatase induction leading to estrogen receptor alpha activation via increased estradiol","short_name":"Aromatase induction leading to estrogen receptor alpha activation via increased estradiol","created_at":"2024-11-22T15:12:56.000-05:00","updated_at":"2025-04-03T15:56:52.000-04:00","corresponding_author":{"id":17647,"created_at":"2023-07-11T11:09:43.000-04:00","updated_at":"2025-07-23T12:41:53.000-04:00","subscribed":true,"novice":true},"aop_stressors":[{"stressor_id":556,"stressor_name":"Vinclozolin"},{"stressor_id":177,"stressor_name":"atrazine"},{"stressor_id":825,"stressor_name":"Isobutylmethylxanthine"},{"stressor_id":826,"stressor_name":"Aldrin"},{"stressor_id":827,"stressor_name":"Technical chlordane"},{"stressor_id":103,"stressor_name":"Cypermethrin"},{"stressor_id":650,"stressor_name":"Methyl parathion"},{"stressor_id":345,"stressor_name":"Endosulfan"},{"stressor_id":828,"stressor_name":"Methoxychlor"},{"stressor_id":829,"stressor_name":"Oxadiazon"},{"stressor_id":830,"stressor_name":"Metolachlor"},{"stressor_id":304,"stressor_name":"Tributyltin"},{"stressor_id":128,"stressor_name":"Benomyl"},{"stressor_id":562,"stressor_name":"p,p'-DDE"}],"aop_mies":[{"event_id":2293,"event":"Aromatase, induction","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":1076,"event":"Increased, circulating estrogen levels","event_type":"KeyEvent"},{"event_id":2294,"event":"Plasma estradiol, increased","event_type":"KeyEvent"},{"event_id":2251,"event":"Estradiol availability, increased","event_type":"KeyEvent"}],"aop_aos":[{"event_id":1065,"event":"Activation, estrogen receptor alpha","event_type":"AdverseOutcome"}],"relationships":[{"relation":4177,"upstream_event_id":2293,"upstream_event":"Aromatase, induction","downstream_event_id":1076,"downstream_event":"Increased, circulating estrogen levels"},{"relation":4181,"upstream_event_id":1076,"upstream_event":"Increased, circulating estrogen levels","downstream_event_id":2251,"downstream_event":"Estradiol availability, increased"},{"relation":4178,"upstream_event_id":1076,"upstream_event":"Increased, circulating estrogen levels","downstream_event_id":2294,"downstream_event":"Plasma estradiol, increased"},{"relation":4179,"upstream_event_id":2294,"upstream_event":"Plasma estradiol, increased","downstream_event_id":2251,"downstream_event":"Estradiol availability, increased"},{"relation":4180,"upstream_event_id":2251,"upstream_event":"Estradiol availability, increased","downstream_event_id":1065,"downstream_event":"Activation, estrogen receptor alpha"}]}