{"id":578,"title":"AhR activation leading to cancer progression via immunosuppression","short_name":"AhR activation leading to cancer progression","created_at":"2025-05-15T10:42:07.000-04:00","updated_at":"2026-02-25T04:39:30.000-05:00","corresponding_author":{"id":19966,"created_at":"2025-04-22T04:34:52.000-04:00","updated_at":"2026-02-24T05:33:34.000-05:00","subscribed":true,"novice":true},"aop_stressors":[{"stressor_id":249,"stressor_name":"2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)"}],"aop_mies":[{"event_id":18,"event":"Activation, AhR","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":2323,"event":"Over-expression of PD-L1 in cancer cells","event_type":"KeyEvent"},{"event_id":2324,"event":"Increased of Treg/Th17 cell ratio","event_type":"KeyEvent"},{"event_id":2326,"event":"CTL cytotoxic activity disruption","event_type":"KeyEvent"}],"aop_aos":[{"event_id":1971,"event":"Increased, tumor growth","event_type":"AdverseOutcome"}],"relationships":[{"relation":4375,"upstream_event_id":18,"upstream_event":"Activation, AhR","downstream_event_id":2323,"downstream_event":"Over-expression of PD-L1 in cancer cells"},{"relation":4376,"upstream_event_id":2323,"upstream_event":"Over-expression of PD-L1 in cancer cells","downstream_event_id":2324,"downstream_event":"Increased of Treg/Th17 cell ratio"},{"relation":4674,"upstream_event_id":2324,"upstream_event":"Increased of Treg/Th17 cell ratio","downstream_event_id":2326,"downstream_event":"CTL cytotoxic activity disruption"},{"relation":4675,"upstream_event_id":2326,"upstream_event":"CTL cytotoxic activity disruption","downstream_event_id":1971,"downstream_event":"Increased, tumor growth"}]}