{"id":595,"title":"Emerging OPFRS reproductive outcome pathway","short_name":"OPFRs","created_at":"2025-08-28T22:54:19.000-04:00","updated_at":"2025-11-06T05:11:27.000-05:00","corresponding_author":{"id":20156,"created_at":"2025-07-10T04:53:06.000-04:00","updated_at":"2025-11-20T03:26:35.000-05:00","subscribed":true,"novice":true},"aop_stressors":[],"aop_mies":[{"event_id":112,"event":"Antagonism, Estrogen receptor","event_type":"MolecularInitiatingEvent"},{"event_id":1115,"event":"Increase, Reactive oxygen species","event_type":"MolecularInitiatingEvent"},{"event_id":26,"event":"Antagonism, Androgen receptor","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":1392,"event":"Increase, Oxidative Stress ","event_type":"KeyEvent"},{"event_id":1262,"event":"Apoptosis","event_type":"KeyEvent"},{"event_id":177,"event":"Increase, Mitochondrial dysfunction","event_type":"KeyEvent"},{"event_id":495,"event":"Repressed expression of steroidogenic enzymes ","event_type":"KeyEvent"},{"event_id":2080,"event":"Impaired, blood testis barrier","event_type":"KeyEvent"},{"event_id":1690,"event":"Decrease, circulating testosterone levels ","event_type":"KeyEvent"},{"event_id":1758,"event":"Impaired, Spermatogenesis","event_type":"KeyEvent"},{"event_id":3,"event":"Reduction, 17beta-estradiol synthesis by ovarian granulosa cells","event_type":"KeyEvent"},{"event_id":2366,"event":"ovarian retardation","event_type":"KeyEvent"},{"event_id":2367,"event":"Steroidogenesis Dysregulation","event_type":"KeyEvent"},{"event_id":1837,"event":"decreased oocyte maturation","event_type":"KeyEvent"},{"event_id":2369,"event":"Granulosa cell damage","event_type":"KeyEvent"}],"aop_aos":[{"event_id":520,"event":"Decreased sperm quantity or quality in the adult, Decreased fertility ","event_type":"AdverseOutcome"},{"event_id":1863,"event":"Decrease, Reproduction","event_type":"AdverseOutcome"},{"event_id":1696,"event":"Decrease of egg production and cummulative fecundity","event_type":"AdverseOutcome"}],"relationships":[{"relation":4510,"upstream_event_id":1115,"upstream_event":"Increase, Reactive oxygen species","downstream_event_id":112,"downstream_event":"Antagonism, Estrogen receptor"},{"relation":4511,"upstream_event_id":1115,"upstream_event":"Increase, Reactive oxygen species","downstream_event_id":1392,"downstream_event":"Increase, Oxidative Stress "},{"relation":4512,"upstream_event_id":1392,"upstream_event":"Increase, Oxidative Stress ","downstream_event_id":177,"downstream_event":"Increase, Mitochondrial dysfunction"},{"relation":4513,"upstream_event_id":177,"upstream_event":"Increase, Mitochondrial dysfunction","downstream_event_id":1262,"downstream_event":"Apoptosis"},{"relation":4514,"upstream_event_id":495,"upstream_event":"Repressed expression of steroidogenic enzymes ","downstream_event_id":1690,"downstream_event":"Decrease, circulating testosterone levels "},{"relation":4515,"upstream_event_id":1392,"upstream_event":"Increase, Oxidative Stress ","downstream_event_id":495,"downstream_event":"Repressed expression of steroidogenic enzymes "},{"relation":4516,"upstream_event_id":26,"upstream_event":"Antagonism, Androgen receptor","downstream_event_id":2080,"downstream_event":"Impaired, blood testis barrier"},{"relation":4517,"upstream_event_id":2080,"upstream_event":"Impaired, blood testis barrier","downstream_event_id":520,"downstream_event":"Decreased sperm quantity or quality in the adult, Decreased fertility "},{"relation":4518,"upstream_event_id":520,"upstream_event":"Decreased sperm quantity or quality in the adult, Decreased fertility ","downstream_event_id":1863,"downstream_event":"Decrease, Reproduction"},{"relation":4519,"upstream_event_id":1690,"upstream_event":"Decrease, circulating testosterone levels ","downstream_event_id":1758,"downstream_event":"Impaired, Spermatogenesis"},{"relation":4520,"upstream_event_id":1758,"upstream_event":"Impaired, Spermatogenesis","downstream_event_id":520,"downstream_event":"Decreased sperm quantity or quality in the adult, Decreased fertility "},{"relation":4521,"upstream_event_id":1758,"upstream_event":"Impaired, Spermatogenesis","downstream_event_id":1863,"downstream_event":"Decrease, Reproduction"},{"relation":4523,"upstream_event_id":3,"upstream_event":"Reduction, 17beta-estradiol synthesis by ovarian granulosa cells","downstream_event_id":1696,"downstream_event":"Decrease of egg production and cummulative fecundity"},{"relation":4524,"upstream_event_id":1696,"upstream_event":"Decrease of egg production and cummulative fecundity","downstream_event_id":1863,"downstream_event":"Decrease, Reproduction"}]}