{"id":609,"title":"Activation, estrogen receptor alpha leads to prolonged estrus cycle via decreased kisspeptin release","short_name":"Activation, ERα leads to prolonged estrus cycle via decreased kisspeptin","created_at":"2025-10-02T12:18:23.000-04:00","updated_at":"2026-03-18T16:03:04.000-04:00","corresponding_author":{"id":17529,"created_at":"2023-05-10T14:47:26.000-04:00","updated_at":"2026-04-17T13:15:44.000-04:00","subscribed":true,"novice":true},"aop_stressors":[],"aop_mies":[{"event_id":1065,"event":"Activation, estrogen receptor alpha","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":968,"event":"Decreased, release of kisspeptin from anteroventral periventricular nucleus (AVPV) neurons ","event_type":"KeyEvent"},{"event_id":530,"event":"Decreased, GnRH pulsatility/release","event_type":"KeyEvent"},{"event_id":1986,"event":"Decreased, Gonadotropins","event_type":"KeyEvent"}],"aop_aos":[{"event_id":1075,"event":"prolonged, estrus cycle","event_type":"AdverseOutcome"}],"relationships":[{"relation":4599,"upstream_event_id":1065,"upstream_event":"Activation, estrogen receptor alpha","downstream_event_id":968,"downstream_event":"Decreased, release of kisspeptin from anteroventral periventricular nucleus (AVPV) neurons "},{"relation":4600,"upstream_event_id":968,"upstream_event":"Decreased, release of kisspeptin from anteroventral periventricular nucleus (AVPV) neurons ","downstream_event_id":530,"downstream_event":"Decreased, GnRH pulsatility/release"},{"relation":4601,"upstream_event_id":530,"upstream_event":"Decreased, GnRH pulsatility/release","downstream_event_id":1075,"downstream_event":"prolonged, estrus cycle"},{"relation":4602,"upstream_event_id":1986,"upstream_event":"Decreased, Gonadotropins","downstream_event_id":1075,"downstream_event":"prolonged, estrus cycle"}]}