{"id":618,"title":"PPARgamma activation leads to a diminished vaccine response","short_name":"PPARgamma activation leads to a diminished vaccine response","created_at":"2025-12-03T10:28:49.000-05:00","updated_at":"2026-01-16T11:46:51.000-05:00","corresponding_author":{"id":19966,"created_at":"2025-04-22T04:34:52.000-04:00","updated_at":"2026-02-24T05:33:34.000-05:00","subscribed":true,"novice":true},"aop_stressors":[],"aop_mies":[{"event_id":1028,"event":"Activation of specific nuclear receptors, PPAR-gamma activation","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":202,"event":"Inhibition, Nuclear factor kappa B (NF-kB)","event_type":"KeyEvent"},{"event_id":2394,"event":"Diminished survival of naive B lymphocytes","event_type":"KeyEvent"},{"event_id":2395,"event":"Diminished proliferation of activated B lymphocytes ","event_type":"KeyEvent"},{"event_id":2396,"event":"Diminished differentiation of activated B lymphocytes ","event_type":"KeyEvent"},{"event_id":2398,"event":"Reduced antibody production","event_type":"KeyEvent"}],"aop_aos":[{"event_id":2397,"event":"Diminished vaccine response","event_type":"AdverseOutcome"}],"relationships":[{"relation":4663,"upstream_event_id":202,"upstream_event":"Inhibition, Nuclear factor kappa B (NF-kB)","downstream_event_id":2394,"downstream_event":"Diminished survival of naive B lymphocytes"},{"relation":4664,"upstream_event_id":202,"upstream_event":"Inhibition, Nuclear factor kappa B (NF-kB)","downstream_event_id":2395,"downstream_event":"Diminished proliferation of activated B lymphocytes "},{"relation":4665,"upstream_event_id":202,"upstream_event":"Inhibition, Nuclear factor kappa B (NF-kB)","downstream_event_id":2396,"downstream_event":"Diminished differentiation of activated B lymphocytes "},{"relation":4666,"upstream_event_id":2396,"upstream_event":"Diminished differentiation of activated B lymphocytes ","downstream_event_id":2398,"downstream_event":"Reduced antibody production"},{"relation":4667,"upstream_event_id":2398,"upstream_event":"Reduced antibody production","downstream_event_id":2397,"downstream_event":"Diminished vaccine response"},{"relation":4668,"upstream_event_id":2394,"upstream_event":"Diminished survival of naive B lymphocytes","downstream_event_id":2395,"downstream_event":"Diminished proliferation of activated B lymphocytes "},{"relation":4669,"upstream_event_id":2395,"upstream_event":"Diminished proliferation of activated B lymphocytes ","downstream_event_id":2396,"downstream_event":"Diminished differentiation of activated B lymphocytes "},{"relation":4679,"upstream_event_id":1028,"upstream_event":"Activation of specific nuclear receptors, PPAR-gamma activation","downstream_event_id":202,"downstream_event":"Inhibition, Nuclear factor kappa B (NF-kB)"}]}