{"id":636,"title":"Increase in reactive oxygen species (ROS) leading to human amyotrophic lateral sclerosis (ALS)","short_name":"Increase in ROS leading to human ALS","created_at":"2026-03-13T02:16:33.000-04:00","updated_at":"2026-05-19T02:06:35.000-04:00","corresponding_author":{"id":355,"created_at":"2016-12-05T02:52:54.000-05:00","updated_at":"2026-06-09T03:07:30.000-04:00","subscribed":true,"novice":true},"aop_stressors":[],"aop_mies":[{"event_id":1115,"event":"Increase, Reactive oxygen species","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":177,"event":"Increase, Mitochondrial dysfunction","event_type":"KeyEvent"},{"event_id":188,"event":"Neuroinflammation","event_type":"KeyEvent"},{"event_id":386,"event":"Decrease of neuronal network function","event_type":"KeyEvent"}],"aop_aos":[{"event_id":2416,"event":"human amyotrophic lateral sclerosis (ALS)","event_type":"AdverseOutcome"}],"relationships":[{"relation":4919,"upstream_event_id":1115,"upstream_event":"Increase, Reactive oxygen species","downstream_event_id":177,"downstream_event":"Increase, Mitochondrial dysfunction"},{"relation":4920,"upstream_event_id":177,"upstream_event":"Increase, Mitochondrial dysfunction","downstream_event_id":188,"downstream_event":"Neuroinflammation"},{"relation":4921,"upstream_event_id":188,"upstream_event":"Neuroinflammation","downstream_event_id":386,"downstream_event":"Decrease of neuronal network function"},{"relation":4922,"upstream_event_id":386,"upstream_event":"Decrease of neuronal network function","downstream_event_id":2416,"downstream_event":"human amyotrophic lateral sclerosis (ALS)"}]}