{"id":640,"title":"Activation, estrogen receptor alpha leads to decreased fertility via failure to ovulate","short_name":"Activation, ERα leads to decreased fertility via failure to ovulate","created_at":"2026-04-06T15:02:11.000-04:00","updated_at":"2026-04-06T15:58:54.000-04:00","corresponding_author":{"id":17529,"created_at":"2023-05-10T14:47:26.000-04:00","updated_at":"2026-04-06T12:09:51.000-04:00","subscribed":true,"novice":true},"aop_stressors":[],"aop_mies":[{"event_id":1065,"event":"Activation, estrogen receptor alpha","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":1985,"event":"Increased Kisspeptin levels in anteroventral periventricular nucleus (AVPV)","event_type":"KeyEvent"},{"event_id":1047,"event":"Increased, secretion of GnRH from hypothalamus","event_type":"KeyEvent"},{"event_id":2137,"event":"Increase, Gonadotropins concentration in plasma","event_type":"KeyEvent"},{"event_id":2402,"event":"Increased, estradiol (E2) production in ovaries ","event_type":"KeyEvent"},{"event_id":2294,"event":"Plasma estradiol, increased","event_type":"KeyEvent"},{"event_id":1075,"event":"prolonged, estrus cycle","event_type":"KeyEvent"}],"aop_aos":[{"event_id":406,"event":"decreased, Fertility","event_type":"AdverseOutcome"}],"relationships":[{"relation":4923,"upstream_event_id":1065,"upstream_event":"Activation, estrogen receptor alpha","downstream_event_id":1985,"downstream_event":"Increased Kisspeptin levels in anteroventral periventricular nucleus (AVPV)"},{"relation":4924,"upstream_event_id":1985,"upstream_event":"Increased Kisspeptin levels in anteroventral periventricular nucleus (AVPV)","downstream_event_id":1047,"downstream_event":"Increased, secretion of GnRH from hypothalamus"},{"relation":4925,"upstream_event_id":1047,"upstream_event":"Increased, secretion of GnRH from hypothalamus","downstream_event_id":2137,"downstream_event":"Increase, Gonadotropins concentration in plasma"},{"relation":4926,"upstream_event_id":2137,"upstream_event":"Increase, Gonadotropins concentration in plasma","downstream_event_id":2402,"downstream_event":"Increased, estradiol (E2) production in ovaries "},{"relation":4927,"upstream_event_id":2402,"upstream_event":"Increased, estradiol (E2) production in ovaries ","downstream_event_id":2294,"downstream_event":"Plasma estradiol, increased"},{"relation":4928,"upstream_event_id":2294,"upstream_event":"Plasma estradiol, increased","downstream_event_id":1075,"downstream_event":"prolonged, estrus cycle"},{"relation":4929,"upstream_event_id":1075,"upstream_event":"prolonged, estrus cycle","downstream_event_id":406,"downstream_event":"decreased, Fertility"}]}