{"id":642,"title":"Intestinal FXR inhibition leading to steatohepatitis via gut‑liver axis dysregulation","short_name":"Intestinal FXR inhibition to steatohepatitis","created_at":"2026-04-21T22:49:31.000-04:00","updated_at":"2026-04-23T00:56:02.000-04:00","corresponding_author":{"id":585,"created_at":"2018-03-20T08:57:53.000-04:00","updated_at":"2026-04-21T22:48:05.000-04:00","subscribed":true,"novice":true},"aop_stressors":[],"aop_mies":[{"event_id":2421,"event":" Inhibition, Intestinal FXR","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":2422,"event":"Ileal FGF15/FGF19 secretion, decreased","event_type":"KeyEvent"},{"event_id":1931,"event":"Intestinal barrier, disruption","event_type":"KeyEvent"},{"event_id":2423,"event":"Hepatic SHP, decreased","event_type":"KeyEvent"},{"event_id":2424,"event":"Hepatic CYP7A1, increased","event_type":"KeyEvent"},{"event_id":2225,"event":"Disrupted Lipid Storage","event_type":"KeyEvent"},{"event_id":1392,"event":"Increase, Oxidative Stress ","event_type":"KeyEvent"}],"aop_aos":[{"event_id":1489,"event":"Increase, Steatohepatitis","event_type":"AdverseOutcome"}],"relationships":[{"relation":4934,"upstream_event_id":2421,"upstream_event":" Inhibition, Intestinal FXR","downstream_event_id":2422,"downstream_event":"Ileal FGF15/FGF19 secretion, decreased"}]}