{"id":645,"title":"Binding and activation of AhR lead to cardiovascular aging","short_name":"Binding and activation of AhR lead to cardiovascular aging","created_at":"2026-07-09T03:29:56.000-04:00","updated_at":"2026-07-09T09:44:07.000-04:00","corresponding_author":{"id":21145,"created_at":"2026-07-07T03:02:23.000-04:00","updated_at":"2026-07-09T03:15:58.000-04:00","subscribed":true,"novice":true},"aop_stressors":[{"stressor_id":860,"stressor_name":"Naphthalene"},{"stressor_id":868,"stressor_name":"Acenaphthene"},{"stressor_id":869,"stressor_name":"Acenaphthylene"},{"stressor_id":870,"stressor_name":"Fluorene"},{"stressor_id":46,"stressor_name":"Phenanthrene"},{"stressor_id":861,"stressor_name":"Anthracene"},{"stressor_id":871,"stressor_name":"Fluoranthene"},{"stressor_id":862,"stressor_name":"Pyrene"},{"stressor_id":864,"stressor_name":"Chrysene"},{"stressor_id":859,"stressor_name":"Benzo(b)fluoranthene"},{"stressor_id":10,"stressor_name":"Benzo(k)fluoranthene"},{"stressor_id":538,"stressor_name":"Benzo(a)pyrene"},{"stressor_id":863,"stressor_name":"Benz(a)anthracene"},{"stressor_id":872,"stressor_name":"Indeno(1,2,3-cd)pyrene"},{"stressor_id":873,"stressor_name":"Dibenz(a,h)anthracene"},{"stressor_id":874,"stressor_name":"Benzo(g,h,i)perylene"}],"aop_mies":[{"event_id":2430,"event":"Aryl hydrocarbon receptor（AhR）activation","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":1392,"event":"Increase, Oxidative Stress ","event_type":"KeyEvent"},{"event_id":2431,"event":"Impact on sirtuins-related aging signaling pathway gene expression","event_type":"KeyEvent"},{"event_id":1194,"event":"Increase, DNA damage","event_type":"KeyEvent"},{"event_id":2432,"event":"Increase, Cell cycle arrest","event_type":"KeyEvent"},{"event_id":2439,"event":"Increase, Telomere attrition","event_type":"KeyEvent"},{"event_id":2434,"event":"Disruption, Mitochondrial dysfunction","event_type":"KeyEvent"},{"event_id":2436,"event":"Increase, Systemic inflammation","event_type":"KeyEvent"},{"event_id":2435,"event":"Increase, Myocardial and vascular structural remodeling","event_type":"KeyEvent"},{"event_id":2437,"event":"Increase, Blood pressure elevation","event_type":"KeyEvent"}],"aop_aos":[{"event_id":2438,"event":"Increase, Cardiovascular aging","event_type":"AdverseOutcome"}],"relationships":[{"relation":5009,"upstream_event_id":2430,"upstream_event":"Aryl hydrocarbon receptor（AhR）activation","downstream_event_id":1392,"downstream_event":"Increase, Oxidative Stress "},{"relation":5010,"upstream_event_id":1392,"upstream_event":"Increase, Oxidative Stress ","downstream_event_id":2431,"downstream_event":"Impact on sirtuins-related aging signaling pathway gene expression"},{"relation":5011,"upstream_event_id":2431,"upstream_event":"Impact on sirtuins-related aging signaling pathway gene expression","downstream_event_id":1194,"downstream_event":"Increase, DNA damage"},{"relation":5012,"upstream_event_id":1194,"upstream_event":"Increase, DNA damage","downstream_event_id":2432,"downstream_event":"Increase, Cell cycle arrest"},{"relation":5013,"upstream_event_id":2432,"upstream_event":"Increase, Cell cycle arrest","downstream_event_id":2439,"downstream_event":"Increase, Telomere attrition"},{"relation":5014,"upstream_event_id":1194,"upstream_event":"Increase, DNA damage","downstream_event_id":2434,"downstream_event":"Disruption, Mitochondrial dysfunction"},{"relation":5015,"upstream_event_id":1392,"upstream_event":"Increase, Oxidative Stress ","downstream_event_id":2436,"downstream_event":"Increase, Systemic inflammation"},{"relation":5016,"upstream_event_id":2431,"upstream_event":"Impact on sirtuins-related aging signaling pathway gene expression","downstream_event_id":2435,"downstream_event":"Increase, Myocardial and vascular structural remodeling"},{"relation":5017,"upstream_event_id":2435,"upstream_event":"Increase, Myocardial and vascular structural remodeling","downstream_event_id":2437,"downstream_event":"Increase, Blood pressure elevation"},{"relation":5018,"upstream_event_id":2435,"upstream_event":"Increase, Myocardial and vascular structural remodeling","downstream_event_id":2438,"downstream_event":"Increase, Cardiovascular aging"}]}