{"id":652,"title":"Inhibition of brain insulin-degrading enzyme (IDE) leads to cognitive decline (adult)","short_name":"IDE and cognitive decline","created_at":"2026-08-31T09:12:13.000-04:00","updated_at":"2026-08-31T09:22:04.000-04:00","corresponding_author":{"id":2683,"created_at":"2020-12-27T13:38:49.000-05:00","updated_at":"2026-07-01T04:13:25.000-04:00","subscribed":true,"novice":true},"aop_stressors":[],"aop_mies":[{"event_id":2448,"event":"Brain insulin-degrading enzyme (IDE), inhibition","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":2449,"event":"Brain amyloid-beta (Aβ) accumulation, increased","event_type":"KeyEvent"},{"event_id":1943,"event":"Hyperphosphorylation of Tau","event_type":"KeyEvent"},{"event_id":1944,"event":"Synaptic dysfunction","event_type":"KeyEvent"}],"aop_aos":[{"event_id":2450,"event":"Cognitive Decline (Adult)","event_type":"AdverseOutcome"}],"relationships":[{"relation":5058,"upstream_event_id":2448,"upstream_event":"Brain insulin-degrading enzyme (IDE), inhibition","downstream_event_id":2449,"downstream_event":"Brain amyloid-beta (Aβ) accumulation, increased"},{"relation":5062,"upstream_event_id":2449,"upstream_event":"Brain amyloid-beta (Aβ) accumulation, increased","downstream_event_id":2450,"downstream_event":"Cognitive Decline (Adult)"},{"relation":5059,"upstream_event_id":2449,"upstream_event":"Brain amyloid-beta (Aβ) accumulation, increased","downstream_event_id":1943,"downstream_event":"Hyperphosphorylation of Tau"},{"relation":5060,"upstream_event_id":1943,"upstream_event":"Hyperphosphorylation of Tau","downstream_event_id":1944,"downstream_event":"Synaptic dysfunction"},{"relation":5061,"upstream_event_id":1944,"upstream_event":"Synaptic dysfunction","downstream_event_id":2450,"downstream_event":"Cognitive Decline (Adult)"}]}