{"id":658,"title":"Activation, estrogen receptor alpha leads to early vaginal opening via increased kisspeptin release","short_name":"Activation, ERα leads to early vaginal opening via increased kisspeptin","created_at":"2026-11-02T04:21:58.000-05:00","updated_at":"2026-11-02T08:03:52.000-05:00","corresponding_author":{"id":21274,"created_at":"2026-10-05T03:20:09.000-04:00","updated_at":"2026-11-02T07:44:31.000-05:00","subscribed":true,"novice":null},"aop_stressors":[],"aop_mies":[{"event_id":1065,"event":"Activation, estrogen receptor alpha","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":1985,"event":"Increased Kisspeptin levels in anteroventral periventricular nucleus (AVPV)","event_type":"KeyEvent"},{"event_id":1047,"event":"Increased, secretion of GnRH from hypothalamus","event_type":"KeyEvent"},{"event_id":2137,"event":"Increase, Gonadotropins concentration in plasma","event_type":"KeyEvent"},{"event_id":2402,"event":"Increased, estradiol (E2) production in ovaries ","event_type":"KeyEvent"},{"event_id":2294,"event":"Plasma estradiol, increased","event_type":"KeyEvent"}],"aop_aos":[{"event_id":2463,"event":"Early vaginal opening","event_type":"AdverseOutcome"}],"relationships":[{"relation":5094,"upstream_event_id":1065,"upstream_event":"Activation, estrogen receptor alpha","downstream_event_id":1985,"downstream_event":"Increased Kisspeptin levels in anteroventral periventricular nucleus (AVPV)"},{"relation":5095,"upstream_event_id":1985,"upstream_event":"Increased Kisspeptin levels in anteroventral periventricular nucleus (AVPV)","downstream_event_id":1047,"downstream_event":"Increased, secretion of GnRH from hypothalamus"},{"relation":5096,"upstream_event_id":1047,"upstream_event":"Increased, secretion of GnRH from hypothalamus","downstream_event_id":2137,"downstream_event":"Increase, Gonadotropins concentration in plasma"},{"relation":5097,"upstream_event_id":2137,"upstream_event":"Increase, Gonadotropins concentration in plasma","downstream_event_id":2402,"downstream_event":"Increased, estradiol (E2) production in ovaries "},{"relation":5098,"upstream_event_id":2402,"upstream_event":"Increased, estradiol (E2) production in ovaries ","downstream_event_id":2294,"downstream_event":"Plasma estradiol, increased"},{"relation":5099,"upstream_event_id":2294,"upstream_event":"Plasma estradiol, increased","downstream_event_id":2463,"downstream_event":"Early vaginal opening"}]}