{"id":71,"title":"Modulation of Adult Leydig Cell Function Subsequent to Glucocorticoid Activation","short_name":"Decreased Adult Testosterone 2","created_at":"2016-11-29T18:41:16.000-05:00","updated_at":"2026-01-11T16:56:06.000-05:00","aop_stressors":[],"aop_mies":[{"event_id":650,"event":"Stimulation of adult Leydig cells via the Adrenal Corticosterone, Increased Glucocorticoid","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":525,"event":"Apoptosis of adult Leydig cells, Decreased testosterone by adult Leydig cells","event_type":"KeyEvent"},{"event_id":651,"event":"Glucocorticoid Receptor mediated alterations in steriodogenic enzymes, Decreased testosterone by adult Leydig cells","event_type":"KeyEvent"},{"event_id":652,"event":"Direct effects of Corticosterone on steroidogenesis, Decreased testosterone by adult Leydig cells","event_type":"KeyEvent"}],"aop_aos":[{"event_id":520,"event":"Decreased sperm quantity or quality in the adult, Decreased fertility ","event_type":"AdverseOutcome"}],"relationships":[]}