{"id":89,"title":"Nicotinic acetylcholine receptor activation followed by desensitization contributes to abnormal foraging and directly leads to colony loss/failure","short_name":"nAChR activation - colony loss 7","created_at":"2016-11-29T18:41:16.000-05:00","updated_at":"2026-01-11T16:56:06.000-05:00","corresponding_author":{"id":198,"created_at":"2014-01-14T10:26:18.000-05:00","updated_at":"2026-05-05T15:07:31.000-04:00","subscribed":true,"novice":true},"aop_stressors":[],"aop_mies":[{"event_id":559,"event":"Activation, Nicotinic acetylcholine receptor","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":663,"event":"Desensitization, Nicotinic acetylcholine receptor","event_type":"KeyEvent"},{"event_id":1243,"event":"Altered, Ca2+-calmodulin activated signal transduction","event_type":"KeyEvent"},{"event_id":341,"event":"Impairment, Learning and memory","event_type":"KeyEvent"},{"event_id":560,"event":"Abnormal, Foraging activity and behavior","event_type":"KeyEvent"},{"event_id":1107,"event":"Weakened, Colony","event_type":"KeyEvent"},{"event_id":1108,"event":"Abnormal, Role change within caste","event_type":"KeyEvent"}],"aop_aos":[{"event_id":563,"event":"Death/Failure, Colony","event_type":"AdverseOutcome"}],"relationships":[{"relation":323,"upstream_event_id":559,"upstream_event":"Activation, Nicotinic acetylcholine receptor","downstream_event_id":663,"downstream_event":"Desensitization, Nicotinic acetylcholine receptor"},{"relation":996,"upstream_event_id":663,"upstream_event":"Desensitization, Nicotinic acetylcholine receptor","downstream_event_id":1243,"downstream_event":"Altered, Ca2+-calmodulin activated signal transduction"},{"relation":997,"upstream_event_id":1243,"upstream_event":"Altered, Ca2+-calmodulin activated signal transduction","downstream_event_id":341,"downstream_event":"Impairment, Learning and memory"},{"relation":340,"upstream_event_id":341,"upstream_event":"Impairment, Learning and memory","downstream_event_id":560,"downstream_event":"Abnormal, Foraging activity and behavior"},{"relation":820,"upstream_event_id":560,"upstream_event":"Abnormal, Foraging activity and behavior","downstream_event_id":1108,"downstream_event":"Abnormal, Role change within caste"},{"relation":821,"upstream_event_id":1108,"upstream_event":"Abnormal, Role change within caste","downstream_event_id":1107,"downstream_event":"Weakened, Colony"},{"relation":822,"upstream_event_id":1107,"upstream_event":"Weakened, Colony","downstream_event_id":563,"downstream_event":"Death/Failure, Colony"},{"relation":823,"upstream_event_id":559,"upstream_event":"Activation, Nicotinic acetylcholine receptor","downstream_event_id":341,"downstream_event":"Impairment, Learning and memory"}]}