AOPs

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Showing 1 to 25 of 591 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
475 Binding of chemicals to ionotropic glutamate receptors leads to impairment of learning and memory via loss of drebrin from dendritic spines of neurons Shihori Tanabe All rights reserved 875: Binding of agonist, Ionotropic glutamate receptors 341: Impairment, Learning and memory Under Development 1.107
379 Binding to ACE2 leading to thrombosis and disseminated intravascular coagulation Shihori Tanabe All rights reserved 1739: Binding to ACE2 1846: Thrombosis and Disseminated Intravascular Coagulation Under Development 1.96
364 Thyroperoxidase inhibition leading to altered visual function via decreased eye size Lucia Vergauwen All rights reserved 279: Thyroperoxidase, Inhibition Under Development 1.35
365 Thyroperoxidase inhibition leading to altered visual function via altered photoreceptor patterning Lucia Vergauwen All rights reserved 279: Thyroperoxidase, Inhibition Under Development 1.35
604 Binding of Alpha 1-Adrenergics to Agonists Leading to Depression LUANA GOMES All rights reserved 2370: Agonism binding, α1-Adrenoreceptor 1346: Increased, depression
594 Micro plastic effect on reproduction Shahena Perveen All rights reserved 1238: Activation of oxidative stress pathway 1277: Reproductive failure
595 Emerging OPFRS reproductive outcome pathway Shahena Perveen All rights reserved
580 Mineralocorticoid Receptor Activation Leading to Increased Body Mass Index Théo Jamay All rights reserved 2331: Activation, Mineralocorticoid Receptor 2335: Increase, body mass index
581 Glucocorticoid receptor (GR) activation during development leads to cognitive function (COG) decrease Marie-Gabrielle Zurich All rights reserved 122: Increase, Glucocorticoid receptor activation 402: Cognitive function, decreased
582 Inhibition of EphA2 phosphorylation leads to liver damage via the ERK/ MDM2/p53 axis Peihua Luo All rights reserved None None
583 Vascular endothelial HER2 inhibition disrupts cardiomyocyte calcium homeostasis via EGFR/STAT3/PTX3 axis leading to cardiac contractile dysfunction Peihua Luo All rights reserved None None
584 SQLE accumulation leads to hepatotoxicity via cholesterol/sphingolipid metabolic disturbance and lysosomal damage Peihua Luo All rights reserved None None
585 AKT Inhibition blocks the autophagy flow through the PRKAA/AMPK pathway and leads to cardiotoxicity Peihua Luo All rights reserved None None
586 The increasing accumulation of HMGB1 in the nucleus causes cardiomyocyte death via HMGB1/HSPB1/CCN2 pathway Peihua Luo All rights reserved None None
647 ROS formation leading to growth inhibition modulated by the Keap1–Nrf2 antioxidant response Ying Wang All rights reserved 1115: Increase, Reactive oxygen species 1521: Decrease, Growth
648 Nanomaterial-induced ferritinophagy activation leading to Parkinson's-like motor dysfunction via iron-dependent ferroptotic neurodegeneration Ying Wang All rights reserved None None
649 Photocatalytic ROS generation by titanium dioxide nanoparticles leading to visual dysfunction and reduced larval survival via retinal photoreceptor oxidative damage Ying Wang All rights reserved None None
650 Polystyrene nanoplastic-induced PPAR signaling dysregulation leading to hepatic steatosis and metabolic dysfunction via oxidative stress-driven lipid metabolism reprogramming Ying Wang All rights reserved None None
652 Inhibition of brain insulin-degrading enzyme (IDE) leads to cognitive decline (adult) Barbara Viviani All rights reserved 2448: Brain insulin-degrading enzyme (IDE), inhibition 2450: Cognitive Decline (Adult)
653 Inhibition to Microsomal Triglyceride Transfer Protein Leads to Steatosis Huan Yang All rights reserved 2452: Inhibition to Microsomal Triglyceride Transfer Protein
636 Increase in reactive oxygen species (ROS) leading to human amyotrophic lateral sclerosis (ALS) Shihori Tanabe All rights reserved 1115: Increase, Reactive oxygen species 2416: human amyotrophic lateral sclerosis (ALS)
607 Per and Polyfluoro Alkylating Substances and Microbiota-Gut-Brain Axis Dhirendra Pratap Singh All rights reserved None None
608 Thyroid Hormone Excess Leading to Reduced, Swimming Performance via Hypomyelination Ki-Tae Kim All rights reserved None None
610 Decreased thyroid hormone levels in the brain regulated via transport, metabolism and TR activation leading to decreased cognition and motor function Nathalie Dierichs All rights reserved
615 Suppression of Keap1 cysteine oxidation leading to liver inflammation Young Jun Kim All rights reserved 2385: Suppression of Keap1 cysteine oxidation 902: Inflammation, Liver