AOPs

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Showing 226 to 250 of 591 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
330 Excessive reactive oxygen species production leading to mortality (4) You Song BY-SA 1115: Increase, Reactive oxygen species 350: Increase, Mortality
322 Alkylation of DNA leading to decreased sperm count Carole Yauk BY-SA 97: Alkylation, DNA 1757: Decrease, Sperm count
323 PPARalpha Agonism Leading to Decreased Viable Offspring via Decreased 11-Ketotestosterone Jennifer Olker BY-SA 227: Activation, PPARα
278 IKK complex inhibition leading to liver injury Nanette Vrijenhoek BY-SA 1574: Inhibition, IKK complex
321 Reduced environmental pH leading to thinner shells in Mytilus edulis James Ducker BY-SA None None
318 Glucocorticoid Receptor activation leading to hepatic steatosis Chander K. Negi BY-SA 122: Increase, Glucocorticoid receptor activation 459: Increase, Liver steatosis
312 Acetylcholinesterase Inhibition leading to Acute Mortality via Impaired Coordination & Movement​ Kristie Sullivan BY-SA 12: Acetylcholinesterase (AchE) Inhibition
311 Deposition of energy leading to population decline via DNA oxidation and oocyte apoptosis You Song BY-SA 1686: Deposition of Energy
310 Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR Jon Doering BY-SA 18: Activation, AhR
309 Luteinizing hormone receptor antagonism leading to reproductive dysfunction Young Jun Kim BY-SA 1691: Antagonism,LH receptor 679: Decline, Population trajectory
304 TBX1 inhibition leading to congenital cardiac conotruncal anomalies Jinsoo Lee BY-SA 1680: Inhibition, TBX1 1685: Anomalies, Congenital cardiac conotruncal
301 Inhibition of Cystathionine Beta synthase leading to impaired the early development of anterior-posterior axis Young Jun Kim BY-SA 1657: Inhibition of cystathionine beta-synthase 1667: Impaired,anterior-posterior axis development
288 Inhibition of 17α-hydrolase/C 10,20-lyase (Cyp17A1) activity leads to birth reproductive defects (cryptorchidism) in male (mammals) Bérénice COLLET BY-SA 1609: Inhibition, Cytochrome P450 enzyme (CYP17A1) activity 1616: Malformation, cryptorchidism - maldescended testis
285 Inhibition of N-linked glycosylation leads to liver injury Marvin Martens BY-SA 1604: Inhibition of N-linked glycosylation 1549: Liver Injury
284 Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress leads to chronic kidney disease Frederic Y. Bois BY-SA 1487: Binding, Thiol/seleno-proteins involved in protection against oxidative stress 1603: Chronic kidney disease
281 Acetylcholinesterase Inhibition Leading to Neurodegeneration Karen Watanabe BY-SA 12: Acetylcholinesterase (AchE) Inhibition 352: N/A, Neurodegeneration
280 α-diketone-induced bronchiolitis obliterans Marvin Martens BY-SA 1584: Interaction of α-diketones with arginine residues 1588: Bronchiolitis obliterans
279 Microtubule interacting drugs lead to peripheral neuropathy Marvin Martens BY-SA 1580: Binding of microtubule stabilizing agents (MSA) to microtubules 1583: Sensory axonal peripheral neuropathy
14 Glucocorticoid Receptor Activation Leading to Increased Disease Susceptibility Carlie LaLone BY-SA 122: Increase, Glucocorticoid receptor activation 323: Increased, Disease susceptibility
276 Inhibition of complex I of the electron transport chain leading to chemical induced Fanconi syndrome Marvin Martens BY-SA 888: Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I) 1564: Chemical induced Fanconi syndrome
275 Histone deacetylase inhibition leads to neural tube defects Marvin Martens BY-SA 1502: Histone deacetylase inhibition 1561: Neural tube defects
274 Histone deacetylase inhibition leads to impeded craniofacial development Marvin Martens BY-SA 1502: Histone deacetylase inhibition 1559: Facial cartilage structures are reduced in size and morphologically distorted
273 Mitochondrial complex inhibition leading to liver injury Wanda van der Stel BY-SA
270 Elevated ATP demand for detoxification and repair mechanisms leading to impaired locomotor activity Christopher Goodchild BY-SA None None
269 Elevated ATP demand for detoxification and repair mechanisms leading to impaired growth and development Christopher Goodchild BY-SA None None