AOPs

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Showing 251 to 275 of 563 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
304 TBX1 inhibition leading to congenital cardiac conotruncal anomalies Jinsoo Lee BY-SA 1680: Inhibition, TBX1 1685: Anomalies, Congenital cardiac conotruncal
393 AOP for thyroid disorder caused by triphenyl phosphate via TRβ activation Fei Li BY-SA 1158: Increased, Hepatic thyroid hormone uptake/transport None
423 Toxicological mechanisms of hepatocyte apoptosis through the PARP1 dependent cell death pathway Fei Li BY-SA 1817: Apoptotic cell death
401 G protein-coupled estrogen receptor 1 (GPER) signal pathway in the lipid metabolism disrupting effects Fei Li BY-SA 2029: protein-coupled estrogen receptor 1 (GPER) activation 1489: Increase, Steatohepatitis
408 Imbalance in redox homeostasis leading to structural damage to tissues Fei Li BY-SA None None
531 VEGFR inhibition leading to Keratinocyte differentiation-associate Hand-foot skin reaction Hui Li BY-SA None None
514 PLK1 Activation leading to hepatocyte apoptosis-associate liver injury via autophagy-mediated excessive COX6A1 degradation and impaired function of mitochondrial respiratory chain complex IV Hui Li BY-SA None None
495 Androgen receptor activation leading to prostate cancer Jianxiang Li BY-SA 25: Agonism, Androgen receptor 2135: Prostate cancer
463 The AOP framwork on silica nanopariticles induced hepatoxicity Tianyu Li BY-SA None None
446 PM-related Adverse outcome pathway frameworks on various systems Tianyu Li BY-SA None None
107 Constitutive androstane receptor activation leading to hepatocellular adenomas and carcinomas in the mouse and the rat Kristin Lichti-Kaiser BY-SA 715: Activation, Constitutive androstane receptor 719: Increase, hepatocellular adenomas and carcinomas Under Review 1.17
496 Androgen receptor agonism leading to reproduction dysfunction （in zebrafish） Hongling Liu BY-SA 25: Agonism, Androgen receptor 442: Decreased, Population trajectory
549 Aromatase inhibition leads to reproductive toxicity (including growth and developmental toxicity) in adult female zebrafish Hongling Liu BY-SA 36: Inhibition, Aromatase
149 Peptide Oxidation Leading to Hypertension Frazer Lowe BY-SA 209: Peptide Oxidation 952: Hypertension Under Development 1.50
148 EGFR Activation Leading to Decreased Lung Function Karsta Luettich BY-SA 941: Activation, EGFR 1250: Decrease, Lung function Under Development 1.51
411 Oxidative stress Leading to Decreased Lung Function Karsta Luettich BY-SA 1392: Increase, Oxidative Stress 1250: Decrease, Lung function
425 Oxidative Stress Leading to Decreased Lung Function via Decreased FOXJ1 Karsta Luettich BY-SA 1392: Increase, Oxidative Stress 1250: Decrease, Lung function
424 Oxidative stress Leading to Decreased Lung Function via CFTR dysfunction Karsta Luettich BY-SA 1392: Increase, Oxidative Stress 1250: Decrease, Lung function
586 The increasing accumulation of HMGB1 in the nucleus causes cardiomyocyte death via HMGB1/HSPB1/CCN2 pathway Peihua Luo All rights reserved None None
582 Inhibition of EphA2 phosphorylation leads to liver damage via the ERK/ MDM2/p53 axis Peihua Luo All rights reserved None None
583 Vascular endothelial HER2 inhibition disrupts cardiomyocyte calcium homeostasis via EGFR/STAT3/PTX3 axis leading to cardiac contractile dysfunction Peihua Luo All rights reserved None None
584 SQLE accumulation leads to hepatotoxicity via cholesterol/sphingolipid metabolic disturbance and lysosomal damage Peihua Luo All rights reserved None None
585 AKT Inhibition blocks the autophagy flow through the PRKAA/AMPK pathway and leads to cardiotoxicity Peihua Luo All rights reserved None None
532 Retinoic acid receptor agonism during cerebellar development leading to impaired locomotor function Diana Lupu Open for adoption 2201: Agonism, Retinoic acid receptor 2231: Locomotor function. Impaired
533 Retinoic acid receptor antagonism during neurodevelopment leading to impaired learning and memory Diana Lupu Open for adoption 2232: Antagonism, Retinoic acid receptors 341: Impairment, Learning and memory