AOPs

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Showing 251 to 275 of 584 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
526 Decreased, Chicken Ovalbumin Upstream Promoter Transcription Factor II (COUP-TFII) leads to Impaired, Spermatogenesis John Frisch BY-SA None 1758: Impaired, Spermatogenesis
527 Decreased, Chicken Ovalbumin Upstream Promoter Transcription Factor II (COUP-TFII) leads to Hypospadias, increased John Frisch BY-SA None 2082: Hypospadias, increased
539 Decreased Sodium/Potassium ATPase activity leads to Heart failure John Frisch BY-SA 1562: Decreased Na/K ATPase activity 1535: Heart failure
540 Oxidative Stress in the Fish Ovary Leads to Reproductive Impairment via Reduced Vitellogenin Production Kevin Brix BY-SA 1115: Increase, Reactive oxygen species 360: Decrease, Population growth rate
541 Excessive ROS generation leading to increased incidence of vascular calcification by VSMC phenotype switching Ruiyang Ding BY-SA None None
543 Inhibition of neuropathy target esterase leading to delayed neuropathy via lysolecithin cell membrane integration Brooke Bowe BY-SA 2262: Neuropathy target esterase, inhibited 2267: Delayed neuropathy, increased
544 Inhibition of neuropathy target esterase leading to delayed neuropathy via increased inflammation Brooke Bowe BY-SA 2262: Neuropathy target esterase, inhibited 2267: Delayed neuropathy, increased
545 Activation, Pregnane-X receptor, NR1I2 leads to increased plasma low-density lipoprotein (LDL) cholesterol via increased cholesterol synthesis John Frisch BY-SA 239: Activation, Pregnane-X receptor, NR1I2 2271: Increased, plasma low-density lipoprotein (LDL) cholesterol
546 Succinate dehydrogenase inactivation leads to cancer through hypoxic-like mechanisms Sylvie Bortoli BY-SA 2118: Succinate dehydrogenase, inhibited 885: Increase, Cancer
547 Androgen receptor agonism leading to long anogenital distance in female offspring Johanna Zilliacus All rights reserved 25: Agonism, Androgen receptor 2365: Anogenital distance (AGD), increased
484 Bisphenol A analogs induce cellular dysfunction in human trophoblast cells in a thyroid hormone receptor-dependent manner: in silico and in vitro analyses Xiaoyun Wu BY-SA None None
485 Thyroid hormone antagonism leading to impaired oligodendrocyte maturation during development and subsequent decreased cognition Eliska Kuchovska BY-SA 1656: Antagonism, Thyroid Receptor 402: Cognitive function, decreased
486 Binding to the extracellular protein laminin leading to decreased cognitive function Eliska Kuchovska BY-SA 2109: Binding, extracellular matrix protein laminin 402: Cognitive function, decreased
487 Unknown MIE altering cholesterol metabolism leading to decreased cognition Eliska Kuchovska BY-SA 1114: Unknown, MIE 402: Cognitive function, decreased
488 Increased reactive oxygen species production leading to decreased cognitive function Eliska Kuchovska BY-SA 1115: Increase, Reactive oxygen species 402: Cognitive function, decreased
489 Inhibition of voltage-gated sodium channels leading to decreased cognition Lidwina Gerner BY-SA 1353: Binding to voltage-gated sodium channel 402: Cognitive function, decreased
490 Co-activation of IP3R and RyR leads to reduced IQ and increased socio-economic burden through non-cholinergic mechanisms Karine Audouze BY-SA
492 Glutathione conjugation leading to reproductive dysfunction via oxidative stress Leonardo Vieira BY-SA 2131: Conjugation, GSH 406: decreased, Fertility
493 ERa inactivation alters AT expansion and functions and leads to insulin resistance and metabolically unhealthy obesity Min Ji Kim BY-SA 2126: Estrogen receptor alpha inactivation 2129: Metabolically unhealthy Obesity
459 AhR activation in the thyroid leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals Prakash Patel Open for adoption 18: Activation, AhR 402: Cognitive function, decreased
461 Deposition of ionising energy leads to population decline via impaired oogenesis and spermatogenesis Knut Erik Tollefsen BY-SA None None
462 Activation of reactive oxygen species leading the atherosclerosis Hiromi Ohara BY-SA 1115: Increase, Reactive oxygen species None
463 The AOP framwork on silica nanopariticles induced hepatoxicity Tianyu Li BY-SA None None
464 Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits Julia Meerman BY-SA 896: Parkinsonian motor deficits
465 Alcohol dehydrogenase leading to reproductive dysfunction Donggon Yoo BY-SA 2045: Increase, Alcohol dehydrogenase None