AOPs

OECD View API
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Showing 251 to 275 of 589 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
393 AOP for thyroid disorder caused by triphenyl phosphate via TRβ activation Fei Li BY-SA 1158: Increased, Hepatic thyroid hormone uptake/transport None
389 Oxygen-evolving complex damage leading to population decline via inhibition of photosynthesis Knut Erik Tollefsen BY-SA 1865: Increase, Oxygen-evolving complex damage
388 Deposition of ionising energy leading to population decline via programmed cell death Knut Erik Tollefsen BY-SA 1686: Deposition of Energy
387 Deposition of ionising energy leading to population decline via mitochondrial dysfunction Knut Erik Tollefsen BY-SA 1686: Deposition of Energy
386 Deposition of ionizing energy leading to population decline via inhibition of photosynthesis Knut Erik Tollefsen BY-SA 1686: Deposition of Energy
385 Viral spike protein interaction with ACE2 leads to microvascular dysfunction, via ACE2 dysregulation Julija Filipovska BY-SA 1739: Binding to ACE2 None
384 Hyperactivation of ACE/Ang-II/AT1R axis leading to chronic kidney disease Young Jun Kim BY-SA 1853: Hyperactivation of ACE/Ang-II/AT1R axis 1603: Chronic kidney disease
378 Dysregulated underperforming Toll Like Receptors (TLRs) leading to high pathogen load Gillina Bezemer BY-SA 1848: Toll Like Receptor (TLR) Dysregulation None
342 Ecdysone receptor hyperactivation leading to mortality via mis-timed activation of nuclear receptor cascade You Song BY-SA 103: Increase, Ecdysone receptor hyperactivation
375 test AOP Kevin Crofton BY-SA None None
373 Mitochondrial dysfunction to metabolic diseases Chander K. Negi BY-SA None None
372 Androgen receptor antagonism leading to testicular cancer Chander K. Negi BY-SA 26: Antagonism, Androgen receptor 1839: Testicular Cancer
371 Photosystem II antagonism leading to growth inhibition via dysregulation of growth hormone You Song BY-SA None None
370 Photosystem II antagonism leading to growth inhibition via suppression of photosynthesis You Song BY-SA None None
369 Photosystem II antagonism leading to growth inhibition via oxidative damage You Song BY-SA None None
368 Cytochrome oxidase inhibition leading to increased nasal lesions Katy Goyak BY-SA 1840: Inhibition, cytochrome oxidase 2312: Increased, nasal lesions
367 Competitive binding to thyroid hormone carrier protein thyroid binding globulin (TBG) leading to altered amphibian metamorphosis Jonathan Haselman BY-SA 1831: Binding, Thyroid binding globulin in serum 1101: Altered, Amphibian metamorphosis
366 Competitive binding to thyroid hormone carrier protein transthyretin (TTR) leading to altered amphibian metamorphosis Jonathan Haselman BY-SA 957: Binding, Transthyretin in serum 1101: Altered, Amphibian metamorphosis
362 Immune mediated hepatitis Jung-Hwa Oh BY-SA 1814: benzoquinone imine and acylglucuronide metabolites 1820: Immune mediated hepatitis
347 Toll-like receptor 4 activation and peroxisome proliferator-activated receptor gamma inactivation leading to pulmonary fibrosis Seokjoo Yoon BY-SA 1458: Pulmonary fibrosis
343 Ecdysone receptor antagonism leading to mortality via mis-timed ecdysone receptor-responsive nuclear receptor cascade You Song BY-SA 2374: Increase, Ecdysone receptor antagonism
331 Reactive oxygen species leading to growth inhibition via lipid peroxidation and cell death You Song BY-SA 1115: Increase, Reactive oxygen species 1521: Decrease, Growth
322 Alkylation of DNA leading to decreased sperm count Carole Yauk BY-SA 97: Alkylation, DNA 1757: Decrease, Sperm count
323 PPARalpha Agonism Leading to Decreased Viable Offspring via Decreased 11-Ketotestosterone Jennifer Olker BY-SA 227: Activation, PPARα
324 Reactive oxygen species leading to growth inhibition via oxidative DNA damage and cell cycle disruption You Song BY-SA 1115: Increase, Reactive oxygen species 1521: Decrease, Growth