AOPs

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Showing 276 to 300 of 567 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
523 Retinoic acid receptor agonism during neurodevelopment leading to microcephaly Diana Lupu Open for adoption 2201: Agonism, Retinoic acid receptor 1978: Increase risk, microcephaly
520 Retinoic acid receptor agonism during neurodevelopment leading to impaired learning and memory Diana Lupu Open for adoption 2201: Agonism, Retinoic acid receptor 341: Impairment, Learning and memory
532 Retinoic acid receptor agonism during cerebellar development leading to impaired locomotor function Diana Lupu Open for adoption 2201: Agonism, Retinoic acid receptor 2231: Locomotor function. Impaired
533 Retinoic acid receptor antagonism during neurodevelopment leading to impaired learning and memory Diana Lupu Open for adoption 2232: Antagonism, Retinoic acid receptors 341: Impairment, Learning and memory
199 ER mediated breast cancer AOP Molly M Morgan BY-SA None None
200 Estrogen receptor activation leading to breast cancer Molly M Morgan Open for adoption 111: Agonism, Estrogen receptor 1193: N/A, Breast Cancer
537 Estrogen receptor agonism leads to reduced fecundity via increased vitellogenin in the liver Jason M. O'Brien BY-SA 111: Agonism, Estrogen receptor 78: Reduction, Cumulative fecundity and spawning
569 Decreased DNA methylation of FAM50B/PTCHD3 leading to IQ loss of children via PI3K-Akt pathway Huimin Ma BY-SA 2309: Decreased DNA methylation of FAM50B/PTCHD3 2121: decreased, Intellectual Quotient
256 Inhibition of mitochondrial DNA polymerase gamma leading to kidney toxicity Angela Mally BY-SA 1481: Inhibition of mitochondrial DNA polymerase gamma (Pol gamma) 814: Occurrence, Kidney toxicity Under Development 1.43
257 Receptor mediated endocytosis and lysosomal overload leading to kidney toxicity Angela Mally BY-SA 1486: Binding of substrate, endocytic receptor 814: Occurrence, Kidney toxicity Under Development 1.43
258 Renal protein alkylation leading to kidney toxicity Angela Mally BY-SA 244: Alkylation, Protein 814: Occurrence, Kidney toxicity Under Development 1.43
442 Binding to voltage gate sodium channels during development leads to cognitive impairment Iris Mangas BY-SA 1353: Binding to voltage-gated sodium channel 402: Cognitive function, decreased WPHA/WNT Endorsed 1.91
106 Chemical binding to tubulin in oocytes leading to aneuploid offspring Francesco Marchetti BY-SA 718: Binding, Tubulin 728: Increase, Aneuploid offspring Under Review 1.11
396 Deposition of ionizing energy leads to population decline via impaired meiosis Erica Maremonti BY-SA 1550: Deposition of Ionizing Energy
261 L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility Luigi Margiotta-Casaluci BY-SA 1529: Blockade, L-Type Calcium Channels 1535: Heart failure Under Development 1.45
262 L-type calcium channel blockade leading to the disruption of cardiac electrophysiology Luigi Margiotta-Casaluci BY-SA None None Under Development 1.45
283 L-type calcium channel blockade leading to hypotension Luigi Margiotta-Casaluci BY-SA None None Under Development 1.45
412 Endothelial cell dysfunction leading to thromboinflammation Luigi Margiotta-Casaluci BY-SA None 1916: Thromboinflammation, Increased Under Development 1.96
279 Microtubule interacting drugs lead to peripheral neuropathy Marvin Martens BY-SA 1580: Binding of microtubule stabilizing agents (MSA) to microtubules 1583: Sensory axonal peripheral neuropathy
241 Latent Transforming Growth Factor beta1 activation leads to pulmonary fibrosis Marvin Martens BY-SA 1468: Activation, Latent Transforming Growth Factor Beta 1 1458: Pulmonary fibrosis
285 Inhibition of N-linked glycosylation leads to liver injury Marvin Martens BY-SA 1604: Inhibition of N-linked glycosylation 1549: Liver Injury
280 α-diketone-induced bronchiolitis obliterans Marvin Martens BY-SA 1584: Interaction of α-diketones with arginine residues 1588: Bronchiolitis obliterans
276 Inhibition of complex I of the electron transport chain leading to chemical induced Fanconi syndrome Marvin Martens BY-SA 888: Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I) 1564: Chemical induced Fanconi syndrome
275 Histone deacetylase inhibition leads to neural tube defects Marvin Martens BY-SA 1502: Histone deacetylase inhibition 1561: Neural tube defects
274 Histone deacetylase inhibition leads to impeded craniofacial development Marvin Martens BY-SA 1502: Histone deacetylase inhibition 1559: Facial cartilage structures are reduced in size and morphologically distorted