AOPs

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Showing 276 to 300 of 584 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
466 Doda decarboxylase leading to mortality Donggon Yoo BY-SA 2051: Decrease, Tyrosine None
467 Knickkopf leading to mortality Donggon Yoo BY-SA 2058: Decrease, 20-hydroxyecdysone None
468 Binding of SARS-CoV-2 to ACE2 leads to hyperinflammation (via cell death) Laure-Alix Clerbaux BY-SA 1739: Binding to ACE2 1868: Hyperinflammation
469 Reactive oxygen speicies overproduction leading to increased digestive morbidity and mortality in generation population Ruiyang Ding BY-SA None None
471 Neuron defect induced early behavioral change Woo-Keun Kim BY-SA 2195: Increase, CNS Neural cell death
472 DNA adduct formation leading to kidney failure Manoe Janssen BY-SA 373: Formation, Pro-mutagenic DNA Adducts 759: Increased, Kidney Failure
473 Energy deposition from internalized Ra-226 decay lower oxygen binding capacity of hemocyanin Danielle Beaton BY-SA 1686: Deposition of Energy
476 Adverse Outcome Pathways diagram related to PBDEs associated male reproductive toxicity Yue Zhang BY-SA
477 Androgen receptor (AR) antagonism leading to hypospadias in male (mammalian) offspring Terje Svingen BY-SA 26: Antagonism, Androgen receptor 2082: Hypospadias, increased
402 Thyroid peroxidase (TPO) inhibition leads to periventricular heterotopia formation in the developing rat brain Katherine (Katie) O'Shaughnessy BY-SA 279: Thyroperoxidase, Inhibition
403 combined unhealthy lifestyle factors leading to metabolic syndrome Gillina Bezemer BY-SA None None
404 Metabolic Syndrome leading to Toll Like Receptor dysregulation Gillina Bezemer BY-SA None None
408 Imbalance in redox homeostasis leading to structural damage to tissues Fei Li BY-SA None None
450 Inhibition of AChE and activation of CYP2E1 leading to sensory axonal peripheral neuropathy and mortality SAROJ AMAR BY-SA 12: Acetylcholinesterase (AchE) Inhibition
451 Interaction with lung resident cell membrane components leads to lung cancer Penny Nymark BY-SA 1495: Substance interaction with the lung resident cell membrane components 1670: Lung cancer
452 Adverse outcome pathway of PM-induced respiratory toxicity li qing BY-SA 2007: Non-coding RNA expression profile alteration 2008: Chronic obstructive pulmonary disease
453 Reactive oxygen species and subsequent oxidative stress lead to increased incidence of digestive morbidity and mortality in the general population Ruiyang Ding BY-SA None None
454 PM2.5-related AOP frameworks on liver diseases Zhou Du BY-SA None None
457 Succinate dehydrogenase inhibition leading to increased insulin resistance through reduction in circulating thyroxine Simon Thomas Open for adoption 2118: Succinate dehydrogenase, inhibited 2119: Increase, Insulin resistance
458 AhR activation in the liver leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals Prakash Patel Open for adoption 18: Activation, AhR 402: Cognitive function, decreased
449 Ceramide synthase inhibition leading to neural tube defects Lola Bajard BY-SA 2023: Inhibition of Ceramide Synthase 1561: Neural tube defects
448 ROS, inflammation, and activation of nAChR lead to increased incidence of cardiovascular morbidity and mortality Ruiyang Ding BY-SA None None
423 Toxicological mechanisms of hepatocyte apoptosis through the PARP1 dependent cell death pathway Fei Li BY-SA 1817: Apoptotic cell death
447 Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways Yann GUEGUEN BY-SA None 759: Increased, Kidney Failure
446 PM-related Adverse outcome pathway frameworks on various systems Tianyu Li BY-SA None None