AOPs

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Showing 301 to 325 of 565 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
63 Cyclooxygenase inhibition leading to reproductive dysfunction Dalma Martinovic-Weigelt BY-SA 79: Inhibition, Cyclooxygenase activity
101 Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of pheromone release Dalma Martinovic-Weigelt BY-SA 79: Inhibition, Cyclooxygenase activity
102 Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition Dalma Martinovic-Weigelt BY-SA 79: Inhibition, Cyclooxygenase activity
103 Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint Dalma Martinovic-Weigelt BY-SA 79: Inhibition, Cyclooxygenase activity
122 Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation Dalma Martinovic-Weigelt BY-SA 798: Inhibition, Prolyl hydroxylases
123 Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription Dalma Martinovic-Weigelt BY-SA 801: modulation, Unknown
430 Binding of SARS-CoV-2 to ACE2 leads to viral infection proliferation Sally Mayasich BY-SA 1739: Binding to ACE2 1939: Viral infection and host-to-host transmission, proliferated Under Development 1.96
464 Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits Julia Meerman BY-SA 896: Parkinsonian motor deficits
436 Inhibition of RALDH2 causes reduced all-trans retinoic acid levels, leading to transposition of the great arteries Gina Mennen BY-SA 1880: Decreased, ALDH1A (RALDH) enzyme activity 1970: transposition of the great arteries
410 GSK3beta inactivation leading to increased mortality via defects in developing inner ear Vid Modic BY-SA 1647: GSK3beta inactivation
399 Inhibition of Fyna leading to increased mortality via decreased eye size (Microphthalmos) Vid Modic BY-SA 1884: Inhibition of Fyna
413 Oxidation and antagonism of reduced glutathione leading to mortality via acute renal failure Carmel Mothersill BY-SA 926: Oxidation, Glutathione (To be considered with MIE) 351: Increased Mortality
638 Co-exposure to microplastics and cadmium leading to progression from NAFLD to liver tumorigenesis Wei Mu BY-SA
479 Mitochondrial complexes inhibition leading to left ventricular function decrease via increased myocardial oxidative stress Sivakumar Murugadoss BY-SA 105: Inhibition, Mitochondrial Electron Transport Chain Complexes 2215: Decrease Left Ventricular function Under Development 1.102
529 Xenobiotic binding to peroxisome proliferator-activated receptors (PPARs) causes dysregulation of lipid metabolism leading to liver steatosis Erik Mylroie BY-SA 2226: Stressor binding PPAR isoforms 459: Increase, Liver steatosis
372 Androgen receptor antagonism leading to testicular cancer Chander K. Negi BY-SA 26: Antagonism, Androgen receptor 1839: Testicular Cancer
373 Mitochondrial dysfunction to metabolic diseases Chander K. Negi BY-SA None None
318 Glucocorticoid Receptor activation leading to hepatic steatosis Chander K. Negi BY-SA 122: Increase, Glucocorticoid receptor activation 459: Increase, Liver steatosis
409 Frustrated phagocytosis leads to malignant mesothelioma Penny Nymark BY-SA 1668: Frustrated phagocytosis 1090: Increased, mesotheliomas
451 Interaction with lung resident cell membrane components leads to lung cancer Penny Nymark BY-SA 1495: Substance interaction with the lung resident cell membrane components 1670: Lung cancer
392 Decreased fibrinolysis and activated bradykinin system leading to hyperinflammation Penny Nymark BY-SA 1868: Hyperinflammation Under Development 1.96
402 Thyroid peroxidase (TPO) inhibition leads to periventricular heterotopia formation in the developing rat brain Katherine (Katie) O'Shaughnessy BY-SA 279: Thyroperoxidase, Inhibition
362 Immune mediated hepatitis Jung-Hwa Oh BY-SA 1814: benzoquinone imine and acylglucuronide metabolites 1820: Immune mediated hepatitis
128 Kidney dysfunction by decreased thyroid hormone Jung-Hwa Oh BY-SA 277: Thyroid hormone synthesis, Decreased 814: Occurrence, Kidney toxicity Under Development 1.40
130 Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity Jung-Hwa Oh BY-SA 828: Inhibition, Phospholipase A 840: Formation, Liver fibrosis Under Development 1.39