AOPs

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Showing 301 to 325 of 591 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
273 Mitochondrial complex inhibition leading to liver injury Wanda van der Stel BY-SA
270 Elevated ATP demand for detoxification and repair mechanisms leading to impaired locomotor activity Christopher Goodchild BY-SA None None
269 Elevated ATP demand for detoxification and repair mechanisms leading to impaired growth and development Christopher Goodchild BY-SA None None
260 CYP2E1 activation and formation of protein adducts leading to neurodegeneration Jelle Broeders BY-SA 1514: Neurodegeneration
259 Sensitization induction of the intestinal tract by food proteins Erwin L Roggen BY-SA None None
245 Reduction in photophosphorylation leading to growth inhibition in aquatic plants Knut Erik Tollefsen BY-SA 1471: Increase, Uncoupling of photophosphorylation 1521: Decrease, Growth
241 Latent Transforming Growth Factor beta1 activation leads to pulmonary fibrosis Marvin Martens BY-SA 1468: Activation, Latent Transforming Growth Factor Beta 1 1458: Pulmonary fibrosis
238 Deposition of energy leading to population decline via DNA strand breaks and oocyte apoptosis Knut Erik Tollefsen BY-SA 1686: Deposition of Energy
98 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to decreased shelter seeking and increased predation Ksenia Groh BY-SA 619: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) 588: Increased, predation
325 Increase in reactive oxygen species leading to growth inhibition via oxidative DNA damage and cell death You Song BY-SA 1115: Increase, Reactive oxygen species 1521: Decrease, Growth Under Development
326 Increase in reactive oxygen species leading to growth inhibition via lipid peroxidation and decreased cell proliferation You Song BY-SA 1115: Increase, Reactive oxygen species 1521: Decrease, Growth Under Development
327 Excessive reactive oxygen species production leading to mortality (1) You Song BY-SA 1115: Increase, Reactive oxygen species 350: Increase, Mortality
328 Excessive reactive oxygen species production leading to mortality (2) You Song BY-SA 1115: Increase, Reactive oxygen species 350: Increase, Mortality
329 Excessive reactive oxygen species production leading to mortality (3) You Song BY-SA 1115: Increase, Reactive oxygen species 350: Increase, Mortality
330 Excessive reactive oxygen species production leading to mortality (4) You Song BY-SA 1115: Increase, Reactive oxygen species 350: Increase, Mortality
332 Increase in reactive oxygen species leading to growth inhibition via protein oxidation and decreased cell proliferation You Song BY-SA 1115: Increase, Reactive oxygen species 1521: Decrease, Growth Under Development
333 Increase in reactive oxygen species leading to growth inhibition via protein oxidation and cell death You Song BY-SA 1115: Increase, Reactive oxygen species 1521: Decrease, Growth Under Development
334 Glucocorticoid Receptor Agonism Leading to Impaired Fin Regeneration Alexander Cole BY-SA 122: Increase, Glucocorticoid receptor activation 360: Decrease, Population growth rate
335 AOP for urothelial carcinogenesis due to chemical cytotoxicity by mitochondrial impairment Nathalia Pereira Souza BY-SA 177: Increase, Mitochondrial dysfunction 1763: Urothelial Tumor
338 DNA methyltransferase inhibition leading to population decline (3) You Song BY-SA 1619: Increase, DNA methyltransferase inhibition
316 Trypsin inhibition leading to pancreatic acinar cell tumors Shigeru Hisada BY-SA 1720: Trypsin inhibition 1725: Pancreatic acinar cell tumors Under Development 1.60
319 Binding to ACE2 leading to lung fibrosis Young Jun Kim BY-SA 1740: Induced dysregulation of ACE2 1276: Lung fibrosis Under Development 1.96
320 Binding of SARS-CoV-2 to ACE2 receptor leading to acute respiratory distress associated mortality Young Jun Kim BY-SA 1739: Binding to ACE2 351: Increased Mortality Under Development 1.96
344 Androgen receptor (AR) antagonism leading to nipple retention (NR) in male (mammalian) offspring Terje Svingen BY-SA 26: Antagonism, Androgen receptor 1786: Nipple retention (NR), increased Under Development 1.108
345 Androgen receptor (AR) antagonism leading to decreased fertility in females Terje Svingen BY-SA 26: Antagonism, Androgen receptor Under Development 1.109