AOPs

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Showing 326 to 350 of 565 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
642 Intestinal FXR inhibition leading to steatohepatitis via gut‑liver axis dysregulation Jung-Hwa Oh BY-SA 2421: Inhibition, Intestinal FXR 1489: Increase, Steatohepatitis
462 Activation of reactive oxygen species leading the atherosclerosis Hiromi Ohara BY-SA 1115: Increase, Reactive oxygen species None
154 Inhibition of Calcineurin Activity Leading to Impaired T-Cell Dependent Antibody Response Takumi Ohishi BY-SA 980: Inhibition, Calcineurin Activity 984: Impairment, T-cell dependent antibody response WPHA/WNT Endorsed 1.38
323 PPARalpha Agonism Leading to Decreased Viable Offspring via Decreased 11-Ketotestosterone Jennifer Olker BY-SA 227: Activation, PPARα
282 Adverse outcome pathway on photochemical toxicity initiated by light exposure Satomi Onoue BY-SA 1115: Increase, Reactive oxygen species 1599: Inflamatory events in light-exposed tissues Under Review 1.49
314 Binding to estrogen receptor (ER)-α in immune cells leading to exacerbation of systemic lupus erythematosus (SLE) Yasuharu Otsubo BY-SA 1710: Binding to estrogen receptor (ER)-α in immune cells 1714: Exacerbation of systemic lupus erythematosus (SLE) Under Development 1.73
444 Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability Deborah Oughton BY-SA 360: Decrease, Population growth rate
535 Binding and activation of GPER leading to learning and memory impairments Zedong Ouyang BY-SA 2029: protein-coupled estrogen receptor 1 (GPER) activation 341: Impairment, Learning and memory
218 Inhibition of CYP7B activity leads to decreased reproductive success via decreased locomotor activity Florence Pagé-Larivière BY-SA 1386: CYP7B activity, inhibition 360: Decrease, Population growth rate
219 Inhibition of CYP7B activity leads to decreased reproductive success via decreased sexual behavior Florence Pagé-Larivière BY-SA 1386: CYP7B activity, inhibition 360: Decrease, Population growth rate
561 Aromatase induction leading to estrogen receptor alpha activation via increased estradiol Martina Panzarea BY-SA 2293: Aromatase, induction 1065: Activation, estrogen receptor alpha
565 17β-Hydroxysteroid dehydrogenase 2, inhibition leading to activation, estrogen receptor alpha Martina Panzarea BY-SA 2250: 17β-Hydroxysteroid dehydrogenase 2, inhibition None
566 Decreased, GnRH pulsatility/release leading to estradiol availability, increased via impaired ovulation Martina Panzarea BY-SA None 2306: Persistent vaginal cornification
504 SULT1E1 inhibition leading to uterine adenocarcinoma via increased estrogen availability at target organ level Martina Panzarea BY-SA 2155: Inhibition of Sulfotransferase E1 (SULT1E1) 1065: Activation, estrogen receptor alpha
271 Inhibition of thyroid peroxidase leading to impaired fertility in fish June-Woo Park BY-SA 279: Thyroperoxidase, Inhibition 78: Reduction, Cumulative fecundity and spawning Under Development 1.59
19 Androgen receptor antagonism leading to adverse effects in the male foetus (mammals) Mukesh Patel Open for adoption 26: Antagonism, Androgen receptor 337: N/A, Impairment of reproductive capacity
458 AhR activation in the liver leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals Prakash Patel Open for adoption 18: Activation, AhR 402: Cognitive function, decreased
459 AhR activation in the thyroid leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals Prakash Patel Open for adoption 18: Activation, AhR 402: Cognitive function, decreased
8 Upregulation of Thyroid Hormone Catabolism via Activation of Hepatic Nuclear Receptors, and Subsequent Adverse Neurodevelopmental Outcomes in Mammals Katie Paul Friedman Open for adoption 239: Activation, Pregnane-X receptor, NR1I2 319: Loss, Cochlear function Under Development 1.9
594 Micro plastic effect on reproduction Shahena Perveen All rights reserved 1238: Activation of oxidative stress pathway 1277: Reproductive failure
595 Emerging OPFRS reproductive outcome pathway Shahena Perveen All rights reserved
39 Covalent Binding, Protein, leading to Increase, Allergic Respiratory Hypersensitivity Response Jessica Ponder BY-SA 396: Covalent Binding, Protein 313: Increase, Allergic Respiratory Hypersensitivity Response Under Development 1.20
113 Glutamate-gated chloride channel activation leading to acute mortality Helen Poynton BY-SA 760: Activation, Glutamate-gated chloride channel
13 Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities Anna Price BY-SA 201: Binding of antagonist, NMDA receptors 341: Impairment, Learning and memory WPHA/WNT Endorsed 1.22
48 Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment. Anna Price BY-SA 875: Binding of agonist, Ionotropic glutamate receptors 341: Impairment, Learning and memory WPHA/WNT Endorsed 1.23