AOPs

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Showing 326 to 350 of 589 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
435 Deposition of ionising energy leads to population decline via pollen abnormal Li Xie BY-SA 1686: Deposition of Energy
419 Aryl hydrocarbon receptor activation leading to impaired lung function through P53 toxicity pathway Dianke Yu BY-SA None 1250: Decrease, Lung function
432 Deposition of Energy by Ionizing Radiation leading to Acute Myeloid Leukemia Dag Anders Brede BY-SA 1686: Deposition of Energy 1955: Acute Myeloid Leukemia
431 Increased tumor necrosis factor (TNF) leading to increased risk of gestational diabetes mellitus (GDM) Qi Wang BY-SA 1950: Increase, TNF 1953: Gestational diabetes mellitus
429 A cholesterol/glucose dysmetabolism initiated Tau-driven AOP toward memory loss (AO) in sporadic Alzheimer's Disease with plausible MIE's plug-ins for environmental neurotoxicants Erwin L Roggen BY-SA None 1941: Memory Loss
427 ACE2 downregulation following SARS-CoV-2 infection triggers dysregulation of RAAS and can lead to heart failure. Evangelos-Panagiotis Daskalopoulos BY-SA 1739: Binding to ACE2 1535: Heart failure
426 SARS-CoV-2 spike protein binding to ACE2 receptors expressed on pericytes leads to endothelial cell dysfunction, microvascular injury and myocardial infarction. Evangelos-Panagiotis Daskalopoulos BY-SA 1739: Binding to ACE2 1934: Myocardial Infarction
425 Oxidative Stress Leading to Decreased Lung Function via Decreased FOXJ1 Karsta Luettich BY-SA 1392: Increase, Oxidative Stress 1250: Decrease, Lung function
424 Oxidative stress Leading to Decreased Lung Function via CFTR dysfunction Karsta Luettich BY-SA 1392: Increase, Oxidative Stress 1250: Decrease, Lung function
421 PPARG activation leading to intrahepatic cholestasis Yuan Jin BY-SA None None
420 Aryl hydrocarbon receptor activation leading to lung cancer through sustained NRF2 toxicity pathway Dianke Yu BY-SA 18: Activation, AhR None
281 Acetylcholinesterase Inhibition Leading to Neurodegeneration Karen Watanabe BY-SA 12: Acetylcholinesterase (AchE) Inhibition 352: N/A, Neurodegeneration
318 Glucocorticoid Receptor activation leading to hepatic steatosis Chander K. Negi BY-SA 122: Increase, Glucocorticoid receptor activation 459: Increase, Liver steatosis
312 Acetylcholinesterase Inhibition leading to Acute Mortality via Impaired Coordination & Movement​ Kristie Sullivan BY-SA 12: Acetylcholinesterase (AchE) Inhibition
311 Deposition of energy leading to population decline via DNA oxidation and oocyte apoptosis You Song BY-SA 1686: Deposition of Energy
310 Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR Jon Doering BY-SA 18: Activation, AhR
309 Luteinizing hormone receptor antagonism leading to reproductive dysfunction Young Jun Kim BY-SA 1691: Antagonism,LH receptor 679: Decline, Population trajectory
304 TBX1 inhibition leading to congenital cardiac conotruncal anomalies Jinsoo Lee BY-SA 1680: Inhibition, TBX1 1685: Anomalies, Congenital cardiac conotruncal
301 Inhibition of Cystathionine Beta synthase leading to impaired the early development of anterior-posterior axis Young Jun Kim BY-SA 1657: Inhibition of cystathionine beta-synthase 1667: Impaired,anterior-posterior axis development
288 Inhibition of 17α-hydrolase/C 10,20-lyase (Cyp17A1) activity leads to birth reproductive defects (cryptorchidism) in male (mammals) Bérénice COLLET BY-SA 1609: Inhibition, Cytochrome P450 enzyme (CYP17A1) activity 1616: Malformation, cryptorchidism - maldescended testis
285 Inhibition of N-linked glycosylation leads to liver injury Marvin Martens BY-SA 1604: Inhibition of N-linked glycosylation 1549: Liver Injury
284 Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress leads to chronic kidney disease Frederic Y. Bois BY-SA 1487: Binding, Thiol/seleno-proteins involved in protection against oxidative stress 1603: Chronic kidney disease
245 Reduction in photophosphorylation leading to growth inhibition in aquatic plants Knut Erik Tollefsen BY-SA 1471: Increase, Uncoupling of photophosphorylation 1521: Decrease, Growth
280 α-diketone-induced bronchiolitis obliterans Marvin Martens BY-SA 1584: Interaction of α-diketones with arginine residues 1588: Bronchiolitis obliterans
279 Microtubule interacting drugs lead to peripheral neuropathy Marvin Martens BY-SA 1580: Binding of microtubule stabilizing agents (MSA) to microtubules 1583: Sensory axonal peripheral neuropathy