AOPs

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Showing 351 to 375 of 558 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
13 Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities Anna Price BY-SA 201: Binding of antagonist, NMDA receptors 341: Impairment, Learning and memory WPHA/WNT Endorsed 1.22
374 Binding of Sars-CoV-2 spike protein to ACE 2 receptors expressed on brain cells (neuronal and non-neuronal) leads to neuroinflammation resulting in encephalitis Anna Price BY-SA 1739: Binding to ACE2 1841: Encephalitis Under Development 1.96
452 Adverse outcome pathway of PM-induced respiratory toxicity li qing BY-SA 2007: Non-coding RNA expression profile alteration 2008: Chronic obstructive pulmonary disease
506 Binding of Influenza A Virus (IAV) to Sialic Acid Glycan Receptor leads to viral infection proliferation Jessica Resnick All rights reserved 2158: Influenza A Virus (IAV) binds sialic acid glycan receptor 2194: Influenza A Virus (IAV) shedding and transmission
460 Antagonism of Smoothened receptor leading to orofacial clefting Jacob Reynolds BY-SA 2027: Antagonism, Smoothened receptor 2042: Increase, Orofacial clefting Under Review 1.101
502 Decrease, cholesterol synthesis leads to orofacial clefting Jacob Reynolds BY-SA None 2042: Increase, Orofacial clefting Under Development 1.101
491 Decrease, GLI1/2 target gene expression leads to orofacial clefting Jacob Reynolds BY-SA 2040: Decrease, GLI1/2 target gene expression 2042: Increase, Orofacial clefting Under Development 1.101
429 A cholesterol/glucose dysmetabolism initiated Tau-driven AOP toward memory loss (AO) in sporadic Alzheimer's Disease with plausible MIE's plug-ins for environmental neurotoxicants Erwin L Roggen BY-SA None 1941: Memory Loss
259 Sensitization induction of the intestinal tract by food proteins Erwin L Roggen BY-SA None None
395 Binding of Sars-CoV-2 spike protein to ACE 2 receptors expressed on pericytes leads to disseminated intravascular coagulation resulting in cerebrovascular disease (stroke) Magda Sachana BY-SA 1739: Binding to ACE2 1875: Cerebrovascular disease (stroke) Under Development 1.96
437 Inhibition of mitochondrial electron transport chain (ETC) complexes leading to kidney toxicity Baki Sadi BY-SA 105: Inhibition, Mitochondrial Electron Transport Chain Complexes 814: Occurrence, Kidney toxicity Under Development 1.99
346 Aromatase inhibition leads to male-biased sex ratio via impacts on gonad differentiation Kelvin Santana Rodriguez BY-SA 36: Inhibition, Aromatase 360: Decrease, Population growth rate WPHA/WNT Endorsed 1.12
480 Mitochondrial complexes inhibition leading to heart failure via decreased ATP production Alexandra Schaffert BY-SA 105: Inhibition, Mitochondrial Electron Transport Chain Complexes 2215: Decrease Left Ventricular function Under Development 1.102
593 Redox cycling of a chemical by mitochondria leads to degeneration of nigrostriatal dopaminergic neurons Stefan Schildknecht BY-SA 2362: Redox cycling of a chemical by mitochondria 896: Parkinsonian motor deficits
358 Chitinase inhibition leading to mortality Simon Schmid BY-SA 1806: Inhibition, Chitinase 350: Increase, Mortality Under Development 1.94
359 Chitobiase inhibition leading to mortality Simon Schmid BY-SA 1807: Inhibition, Chitobiase 350: Increase, Mortality Under Development 1.94
360 Chitin synthase 1 inhibition leading to mortality Simon Schmid BY-SA 1522: Inhibition, Chitin synthase 1 350: Increase, Mortality WPHA/WNT Endorsed 1.94
361 Sulfonylureareceptor binding leading to mortality Simon Schmid BY-SA 1525: Increase, Sulfonylurea receptor binding 350: Increase, Mortality Under Development 1.94
590 Increase of intracellular copper leading to cuproptosis via interference with energy metabolism Sophie Scholz BY-SA 2339: Intracellular copper, increased 2343: Cuproptosis, increased
242 Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity Stefan Scholz Open for adoption 1462: Thiol group of chemicals interact with sulfuhydryl groups of proteins to form thiol adducts
303 Frustrated phagocytosis-induced lung cancer Carole Seidel BY-SA 1668: Frustrated phagocytosis 1670: Lung cancer Under Development 1.86
455 Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced impeded craniofacial development Prarthana Shankar BY-SA 18: Activation, AhR WPHA/WNT Endorsed 1.27
456 Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced cardiovascular toxicity Prarthana Shankar BY-SA 18: Activation, AhR 947: Increase, Early Life Stage Mortality WPHA/WNT Endorsed 1.27
46 AFB1: Mutagenic Mode-of-Action leading to Hepatocellular Carcinoma (HCC) Ted Simon BY-SA 373: Formation, Pro-mutagenic DNA Adducts 378: Tumorigenesis, Hepatocellular carcinoma Under Review 1.8
607 Per and Polyfluoro Alkylating Substances and Microbiota-Gut-Brain Axis Dhirendra Pratap Singh All rights reserved None None