AOPs

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Showing 351 to 375 of 591 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
579 Transthyretin disruption in developing fish leading to projected decline in fish population Adriana Webb BY-SA None None
571 5α-reductase inhibition leading to hypospadias in male (mammalian) offspring Terje Svingen BY-SA 1617: Inhibition, 5α-reductase 2082: Hypospadias, increased
572 BMP4 Suppression Disrupting Cytoskeletal Remodeling Leading to Neural Tube Closure Defects Job Berkhout BY-SA None None
573 Inhibition, cytochrome oxidase leads to Increased, pulmonary edema John Frisch BY-SA 1840: Inhibition, cytochrome oxidase 2316: Increased, pulmonary edema
574 Inhibition, cytochrome oxidase leads to Loss of olfactory function John Frisch BY-SA 1840: Inhibition, cytochrome oxidase 2317: Loss of olfactory function
559 Inhibition of acetylcholinesterase (AChE) leading to arrhythmias Young Jun Kim BY-SA 12: Acetylcholinesterase (AchE) Inhibition 1106: Occurrence, cardiac arrhythmia
561 Aromatase induction leading to estrogen receptor alpha activation via increased estradiol Martina Panzarea BY-SA 2293: Aromatase, induction 1065: Activation, estrogen receptor alpha
562 HCN Channel Inhibition leading to Arrhythmias Young Jun Kim BY-SA 2295: HCN Channel Inhibition 1106: Occurrence, cardiac arrhythmia
568 Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) leads to Inhibition, Feeding John Frisch BY-SA 619: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) 1016: Inhibition, Feeding
569 Decreased DNA methylation of FAM50B/PTCHD3 leading to IQ loss of children via PI3K-Akt pathway Huimin Ma BY-SA 2309: Decreased DNA methylation of FAM50B/PTCHD3 2121: decreased, Intellectual Quotient
570 Decreased testosterone synthesis leading to hypospadias in male (mammalian) offspring Terje Svingen BY-SA None 2082: Hypospadias, increased
563 Aryl hydrocarbon Receptor (AHR) activation causes Premature Ovarian Insufficiency via Bax mediated apoptosis Sapana Kushwaha BY-SA 18: Activation, AhR 2305: Premature ovarian Insufficiency
564 DBDPE-induced inhibition of mitochondrial complex Ⅰ leading to population decline via neurotoxicity and metabotoxicity. lihua Yang BY-SA 1541: Mitochondrial Complex I inhibition
565 17β-Hydroxysteroid dehydrogenase 2, inhibition leading to activation, estrogen receptor alpha Martina Panzarea BY-SA 2250: 17β-Hydroxysteroid dehydrogenase 2, inhibition None
566 Decreased, GnRH pulsatility/release leading to estradiol availability, increased via impaired ovulation Martina Panzarea BY-SA None 2306: Persistent vaginal cornification
567 Binding to plastoquinone B site leading to decreased population growth rate via photosystem II inhibition Li Xie BY-SA 2307: Binding of plastoquinone B (QB) within D1 protein of Photosystem II
553 Inhibition of Voltage-gated sodium channels (Na⁺ channels) leading to heart failure Young Jun Kim BY-SA 584: Inhibition, sodium channel 1535: Heart failure
554 β-adrenergic receptor agonists leading to arrhythmias. Young Jun Kim BY-SA 1038: Activation, beta-2 adrenergic receptor 1106: Occurrence, cardiac arrhythmia
555 Inhibition, Ether-a-go-go (ERG) Voltage-Gated Potassium Channel leading to heart failure Young Jun Kim BY-SA 593: Inhibition, Ether-a-go-go (ERG) voltage-gated potassium channel 1535: Heart failure
556 Decreased Na/K ATPase activity leading to heart failure Young Jun Kim BY-SA 1562: Decreased Na/K ATPase activity 1535: Heart failure
557 β2-Receptor agonist leading to Cardiomyopathy Young Jun Kim BY-SA 1039: Increased activity, beta-2 adrenergic receptor 2157: Abnormal Cardiac Structure and Function
558 Phosphodiesterase inhibition leading to heart failure Young Jun Kim BY-SA 2288: Phosphodiesterase inhibition 1535: Heart failure
596 Excessive reactive oxygen species leading to growth inhibition via protein oxidation and cell injury/death You Song BY-SA 1115: Increase, Reactive oxygen species 1521: Decrease, Growth
605 Thyroid Peroxidase Inhibition Leading to Reduced, Swimming Performance via Hypomyelination Ki-Tae Kim BY-SA 279: Thyroperoxidase, Inhibition
603 Excessive reactive oxygen species leading to growth inhibition via protein oxidation and cell cycle disruption You Song BY-SA 1115: Increase, Reactive oxygen species 1521: Decrease, Growth