AOPs

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Showing 351 to 375 of 589 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
278 IKK complex inhibition leading to liver injury Nanette Vrijenhoek BY-SA 1574: Inhibition, IKK complex
276 Inhibition of complex I of the electron transport chain leading to chemical induced Fanconi syndrome Marvin Martens BY-SA 888: Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I) 1564: Chemical induced Fanconi syndrome
275 Histone deacetylase inhibition leads to neural tube defects Marvin Martens BY-SA 1502: Histone deacetylase inhibition 1561: Neural tube defects
274 Histone deacetylase inhibition leads to impeded craniofacial development Marvin Martens BY-SA 1502: Histone deacetylase inhibition 1559: Facial cartilage structures are reduced in size and morphologically distorted
273 Mitochondrial complex inhibition leading to liver injury Wanda van der Stel BY-SA
238 Deposition of energy leading to population decline via DNA strand breaks and oocyte apoptosis Knut Erik Tollefsen BY-SA 1686: Deposition of Energy
241 Latent Transforming Growth Factor beta1 activation leads to pulmonary fibrosis Marvin Martens BY-SA 1468: Activation, Latent Transforming Growth Factor Beta 1 1458: Pulmonary fibrosis
260 CYP2E1 activation and formation of protein adducts leading to neurodegeneration Jelle Broeders BY-SA 1514: Neurodegeneration
242 Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity Stefan Scholz Open for adoption 1462: Thiol group of chemicals interact with sulfuhydryl groups of proteins to form thiol adducts
377 Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS) Gillina Bezemer BY-SA 1842: Prolonged TLR9 activation
400 Inhibition of CYP26B1 activity in fetal testis leading to reduced fertility Terje Svingen BY-SA 1887: Inhibition of CYP26B1 activity 406: decreased, Fertility
399 Inhibition of Fyna leading to increased mortality via decreased eye size (Microphthalmos) Vid Modic BY-SA 1884: Inhibition of Fyna
396 Deposition of ionizing energy leads to population decline via impaired meiosis Erica Maremonti BY-SA 1550: Deposition of Ionizing Energy
389 Oxygen-evolving complex damage leading to population decline via inhibition of photosynthesis Knut Erik Tollefsen BY-SA 1865: Increase, Oxygen-evolving complex damage
388 Deposition of ionising energy leading to population decline via programmed cell death Knut Erik Tollefsen BY-SA 1686: Deposition of Energy
387 Deposition of ionising energy leading to population decline via mitochondrial dysfunction Knut Erik Tollefsen BY-SA 1686: Deposition of Energy
386 Deposition of ionizing energy leading to population decline via inhibition of photosynthesis Knut Erik Tollefsen BY-SA 1686: Deposition of Energy
385 Viral spike protein interaction with ACE2 leads to microvascular dysfunction, via ACE2 dysregulation Julija Filipovska BY-SA 1739: Binding to ACE2 None
384 Hyperactivation of ACE/Ang-II/AT1R axis leading to chronic kidney disease Young Jun Kim BY-SA 1853: Hyperactivation of ACE/Ang-II/AT1R axis 1603: Chronic kidney disease
378 Dysregulated underperforming Toll Like Receptors (TLRs) leading to high pathogen load Gillina Bezemer BY-SA 1848: Toll Like Receptor (TLR) Dysregulation None
342 Ecdysone receptor hyperactivation leading to mortality via mis-timed activation of nuclear receptor cascade You Song BY-SA 103: Increase, Ecdysone receptor hyperactivation
372 Androgen receptor antagonism leading to testicular cancer Chander K. Negi BY-SA 26: Antagonism, Androgen receptor 1839: Testicular Cancer
368 Cytochrome oxidase inhibition leading to increased nasal lesions Katy Goyak BY-SA 1840: Inhibition, cytochrome oxidase 2312: Increased, nasal lesions
367 Competitive binding to thyroid hormone carrier protein thyroid binding globulin (TBG) leading to altered amphibian metamorphosis Jonathan Haselman BY-SA 1831: Binding, Thyroid binding globulin in serum 1101: Altered, Amphibian metamorphosis
366 Competitive binding to thyroid hormone carrier protein transthyretin (TTR) leading to altered amphibian metamorphosis Jonathan Haselman BY-SA 957: Binding, Transthyretin in serum 1101: Altered, Amphibian metamorphosis