AOPs

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Showing 376 to 400 of 584 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
326 Reactive oxygen species leading to growth inhibition via lipid peroxidation and decreased cell proliferation You Song BY-SA 1115: Increase, Reactive oxygen species 1521: Decrease, Growth
327 Excessive reactive oxygen species production leading to mortality (1) You Song BY-SA 1115: Increase, Reactive oxygen species 350: Increase, Mortality
328 Excessive reactive oxygen species production leading to mortality (2) You Song BY-SA 1115: Increase, Reactive oxygen species 350: Increase, Mortality
329 Excessive reactive oxygen species production leading to mortality (3) You Song BY-SA 1115: Increase, Reactive oxygen species 350: Increase, Mortality
330 Excessive reactive oxygen species production leading to mortality (4) You Song BY-SA 1115: Increase, Reactive oxygen species 350: Increase, Mortality
322 Alkylation of DNA leading to decreased sperm count Carole Yauk BY-SA 97: Alkylation, DNA 1757: Decrease, Sperm count
323 PPARalpha Agonism Leading to Decreased Viable Offspring via Decreased 11-Ketotestosterone Jennifer Olker BY-SA 227: Activation, PPARα
334 Glucocorticoid Receptor Agonism Leading to Impaired Fin Regeneration Alexander Cole BY-SA 122: Increase, Glucocorticoid receptor activation 360: Decrease, Population growth rate
335 AOP for urothelial carcinogenesis due to chemical cytotoxicity by mitochondrial impairment Nathalia Pereira Souza BY-SA 177: Increase, Mitochondrial dysfunction 1763: Urothelial Tumor
338 DNA methyltransferase inhibition leading to population decline (3) You Song BY-SA 1619: Increase, DNA methyltransferase inhibition
331 Reactive oxygen species leading to growth inhibition via lipid peroxidation and cell death You Song BY-SA 1115: Increase, Reactive oxygen species 1521: Decrease, Growth
627 Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated mitochondrial dysfunction You Song BY-SA 2410: Increase, 11β-Hydroxysteroid dehydrogenase type 1 activity Under Development
628 Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated oxidative stress You Song BY-SA 2410: Increase, 11β-Hydroxysteroid dehydrogenase type 1 activity Under Development
629 Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated endoplasmic reticulum stress You Song BY-SA 2410: Increase, 11β-Hydroxysteroid dehydrogenase type 1 activity Under Development
630 Decreased 11β-Hydroxysteroid dehydrogenase type 2 activity leading to MASLD progression via insulin resistance-associated mitochondrial dysfunction You Song BY-SA 2409: Decrease, 11β-Hydroxysteroid dehydrogenase type 2 activity None Under Development
624 Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated mitochondrial dysfunction You Song BY-SA 2410: Increase, 11β-Hydroxysteroid dehydrogenase type 1 activity Under Development
625 Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated oxidative stress You Song BY-SA 2410: Increase, 11β-Hydroxysteroid dehydrogenase type 1 activity Under Development
626 Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated endoplasmic reticulum stress You Song BY-SA 2410: Increase, 11β-Hydroxysteroid dehydrogenase type 1 activity Under Development
139 Alkylation of DNA leading to cancer 1 Carole Yauk Open for adoption 97: Alkylation, DNA 885: Increase, Cancer
160 Ionotropic gamma-aminobutyric acid receptor activation mediated neurotransmission inhibition leading to mortality Knut Erik Tollefsen BY-SA 762: Activation, ionotropic GABA Receptor chloride channel 351: Increased Mortality
161 Glutamate-gated chloride channel activation leading to neurotransmission inhibition associated mortality Knut Erik Tollefsen BY-SA 1018: Activation, Glutamate-gated chloride channels 351: Increased Mortality
32 Inhibition of iNOS, hepatotoxicity, and regenerative proliferation leading to liver tumors Undefined BY-SA None None
4 Ecdysone receptor agonism leading to mortality via suppression of Ftz-f1 Knut Erik Tollefsen BY-SA 103: Increase, Ecdysone receptor hyperactivation
19 Androgen receptor antagonism leading to adverse effects in the male foetus (mammals) Mukesh Patel Open for adoption 26: Antagonism, Androgen receptor 337: N/A, Impairment of reproductive capacity
26 Calcium-mediated neuronal ROS production and energy imbalance Lyle Burgoon Open for adoption 51: Inhibition, Ca++ ATPase 1392: Increase, Oxidative Stress