AOPs

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Showing 401 to 425 of 591 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
428 Binding of S-protein to ACE2 in enterocytes induces ACE2 dysregulation leading to gut dysbiosis Laure-Alix Clerbaux BY-SA 1739: Binding to ACE2 None Under Development 1.96
430 Binding of SARS-CoV-2 to ACE2 leads to viral infection proliferation Sally Mayasich BY-SA 1739: Binding to ACE2 1939: Viral infection and host-to-host transmission, proliferated Under Development 1.96
437 Inhibition of mitochondrial electron transport chain (ETC) complexes leading to kidney toxicity Baki Sadi BY-SA 105: Inhibition, Mitochondrial Electron Transport Chain Complexes 814: Occurrence, Kidney toxicity Under Development 1.99
442 Binding to voltage gate sodium channels during development leads to cognitive impairment Iris Mangas BY-SA 1353: Binding to voltage-gated sodium channel 402: Cognitive function, decreased WPHA/WNT Endorsed 1.91
439 Activation of the AhR leading to metastatic breast cancer Louise Benoit BY-SA 18: Activation, AhR 1982: metastatic breast cancer Under Review 1.105
440 Hypothalamus estrogen receptors activity suppression leading to ovarian cancer via ovarian epithelial cell hyperplasia Kalyan Gayen BY-SA 1046: Suppression, Estrogen receptor (ER) activity Under Development 1.104
455 Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced impeded craniofacial development Prarthana Shankar BY-SA 18: Activation, AhR WPHA/WNT Endorsed 1.27
456 Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced cardiovascular toxicity Prarthana Shankar BY-SA 18: Activation, AhR 947: Increase, Early Life Stage Mortality WPHA/WNT Endorsed 1.27
460 Antagonism of Smoothened receptor leading to orofacial clefting Jacob Reynolds BY-SA 2027: Antagonism, Smoothened receptor 2042: Increase, Orofacial clefting Under Review 1.101
474 Succinate dehydrogenase inactivation leads to cancer by promoting EMT Sylvie Bortoli BY-SA 2118: Succinate dehydrogenase, inhibited 885: Increase, Cancer Under Development 1.106
374 Binding of Sars-CoV-2 spike protein to ACE 2 receptors expressed on brain cells (neuronal and non-neuronal) leads to neuroinflammation resulting in encephalitis Anna Price BY-SA 1739: Binding to ACE2 1841: Encephalitis Under Development 1.96
376 Androgen receptor agonism leading to male-biased sex ratio Dan Villeneuve BY-SA 25: Agonism, Androgen receptor 360: Decrease, Population growth rate WPHA/WNT Endorsed 1.12
381 Binding of viral S-glycoprotein to ACE2 receptor leading to dysgeusia Young Jun Kim BY-SA 1739: Binding to ACE2 1850: dysgeusia Under Development 1.96
382 Angiotensin II type 1 receptor (AT1R) agonism leading to lung fibrosis Young Jun Kim BY-SA 1851: Binding of agonist, Angiotensin II receptor type 1 receptor (AT1R) 1276: Lung fibrosis Under Development 1.96
383 Inhibition of Angiotensin-converting enzyme 2 leading to liver fibrosis Young Jun Kim BY-SA 1740: Induced dysregulation of ACE2 344: Increase, Liver fibrosis Under Development 1.96
392 Decreased fibrinolysis and activated bradykinin system leading to hyperinflammation Penny Nymark BY-SA 1868: Hyperinflammation Under Development 1.96
394 SARS-CoV-2 infection of olfactory epithelium leading to impaired olfactory function (short-term anosmia) Sandra Coecke BY-SA 1739: Binding to ACE2 1873: impaired olfactory function (anosmia) Under Development 1.96
395 Binding of Sars-CoV-2 spike protein to ACE 2 receptors expressed on pericytes leads to disseminated intravascular coagulation resulting in cerebrovascular disease (stroke) Magda Sachana BY-SA 1739: Binding to ACE2 1875: Cerebrovascular disease (stroke) Under Development 1.96
397 Bulky DNA adducts leading to mutations Carole Yauk BY-SA 1879: Bulky DNA adducts, increase 185: Increase, Mutations Under Development 1.11
256 Inhibition of mitochondrial DNA polymerase gamma leading to kidney toxicity Angela Mally BY-SA 1481: Inhibition of mitochondrial DNA polymerase gamma (Pol gamma) 814: Occurrence, Kidney toxicity Under Development 1.43
257 Receptor mediated endocytosis and lysosomal overload leading to kidney toxicity Angela Mally BY-SA 1486: Binding of substrate, endocytic receptor 814: Occurrence, Kidney toxicity Under Development 1.43
258 Renal protein alkylation leading to kidney toxicity Angela Mally BY-SA 244: Alkylation, Protein 814: Occurrence, Kidney toxicity Under Development 1.43
261 L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility Luigi Margiotta-Casaluci BY-SA 1529: Blockade, L-Type Calcium Channels 1535: Heart failure Under Development 1.45
262 L-type calcium channel blockade leading to the disruption of cardiac electrophysiology Luigi Margiotta-Casaluci BY-SA None None Under Development 1.45
263 Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased cell proliferation You Song BY-SA 1446: Decrease, Coupling of oxidative phosphorylation 1521: Decrease, Growth WPHA/WNT Endorsed 1.92