AOPs

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Showing 426 to 450 of 558 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
329 Excessive reactive oxygen species production leading to mortality (3) You Song BY-SA 1115: Increase, Reactive oxygen species 350: Increase, Mortality
330 Excessive reactive oxygen species production leading to mortality (4) You Song BY-SA 1115: Increase, Reactive oxygen species 350: Increase, Mortality
332 Reactive oxygen species leading to growth inhibition via protein oxidation and decreased cell proliferation You Song BY-SA 1115: Increase, Reactive oxygen species 1521: Decrease, Growth
333 Reactive oxygen species leading to growth inhibition via protein oxidation and cell death You Song BY-SA 1115: Increase, Reactive oxygen species 1521: Decrease, Growth
338 DNA methyltransferase inhibition leading to population decline (3) You Song BY-SA 1619: Increase, DNA methyltransferase inhibition
331 Reactive oxygen species leading to growth inhibition via lipid peroxidation and cell death You Song BY-SA 1115: Increase, Reactive oxygen species 1521: Decrease, Growth
324 Reactive oxygen species leading to growth inhibition via oxidative DNA damage and cell cycle disruption You Song BY-SA 1115: Increase, Reactive oxygen species 1521: Decrease, Growth
335 AOP for urothelial carcinogenesis due to chemical cytotoxicity by mitochondrial impairment Nathalia Pereira Souza BY-SA 177: Increase, Mitochondrial dysfunction 1763: Urothelial Tumor
302 Lung surfactant function inhibition leading to decreased lung function Jorid Birkelund Sørli BY-SA 1672: Inhibition of lung surfactant function 1250: Decrease, Lung function Under Development 1.87
618 PPARgamma activation leads to a diminished vaccine response Léo SPORTES-MILOT BY-SA 1028: Activation of specific nuclear receptors, PPAR-gamma activation 2397: Diminished vaccine response
578 AhR activation leading to cancer progression via immunosuppression Léo SPORTES-MILOT BY-SA 18: Activation, AhR 1971: Increased, tumor growth
312 Acetylcholinesterase Inhibition leading to Acute Mortality via Impaired Coordination & Movement​ Kristie Sullivan BY-SA 12: Acetylcholinesterase (AchE) Inhibition
152 Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity Kristie Sullivan BY-SA 957: Binding, Transthyretin in serum 402: Cognitive function, decreased Under Development 1.41
575 Decreased testosterone synthesis leading to increased nipple retention (NR) in male (rodent) offspring Terje Svingen BY-SA None 1786: Nipple retention (NR), increased
576 5α-reductase inhibition leading to increased nipple retention (NR) in male (rodent) offspring Terje Svingen BY-SA 1617: Inhibition, 5α-reductase 1786: Nipple retention (NR), increased
305 5α-reductase inhibition leading to short anogenital distance (AGD) in male (mammalian) offspring Terje Svingen BY-SA 1617: Inhibition, 5α-reductase 1688: anogenital distance (AGD), decreased Under Review 1.90
306 Androgen receptor (AR) antagonism leading to short anogenital distance (AGD) in male (mammalian) offspring Terje Svingen BY-SA 26: Antagonism, Androgen receptor 1688: anogenital distance (AGD), decreased Under Review 1.90
570 Decreased testosterone synthesis leading to hypospadias in male (mammalian) offspring Terje Svingen BY-SA None 2082: Hypospadias, increased
571 5α-reductase inhibition leading to hypospadias in male (mammalian) offspring Terje Svingen BY-SA 1617: Inhibition, 5α-reductase 2082: Hypospadias, increased
400 Inhibition of CYP26B1 activity in fetal testis leading to reduced fertility Terje Svingen BY-SA 1887: Inhibition of CYP26B1 activity 406: decreased, Fertility
477 Androgen receptor (AR) antagonism leading to hypospadias in male (mammalian) offspring Terje Svingen BY-SA 26: Antagonism, Androgen receptor 2082: Hypospadias, increased
398 Decreased ALDH1A (RALDH) activity leading to decreased fertility via disrupted meiotic initiation of fetal oogonia Terje Svingen BY-SA 1880: Decreased, ALDH1A (RALDH) enzyme activity 406: decreased, Fertility Under Development 1.97
344 Androgen receptor (AR) antagonism leading to nipple retention (NR) in male (mammalian) offspring Terje Svingen BY-SA 26: Antagonism, Androgen receptor 1786: Nipple retention (NR), increased Under Development 1.108
345 Androgen receptor (AR) antagonism leading to decreased fertility in females Terje Svingen BY-SA 26: Antagonism, Androgen receptor Under Development 1.109
307 Decreased testosterone synthesis leading to short anogenital distance (AGD) in male (mammalian) offspring Terje Svingen BY-SA None 1688: anogenital distance (AGD), decreased Under Review 1.90