AOPs

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Showing 426 to 450 of 591 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
264 Uncoupling of oxidative phosphorylation leading to growth inhibition via ATP depletion associated cell death You Song BY-SA 1446: Decrease, Coupling of oxidative phosphorylation 1521: Decrease, Growth Under Development 1.92
265 Uncoupling of oxidative phosphorylation leading to growth inhibition via increased cytosolic calcium You Song BY-SA 1446: Decrease, Coupling of oxidative phosphorylation 1521: Decrease, Growth Under Development 1.92
266 Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased Na-K ATPase activity You Song BY-SA 1446: Decrease, Coupling of oxidative phosphorylation 1521: Decrease, Growth Under Development 1.92
267 Uncoupling of oxidative phosphorylation leading to growth inhibition via glucose depletion You Song BY-SA 1446: Decrease, Coupling of oxidative phosphorylation 1521: Decrease, Growth Under Development 1.92
268 Uncoupling of oxidative phosphorylation leading to growth inhibition via mitochondrial swelling You Song BY-SA 1446: Decrease, Coupling of oxidative phosphorylation 1521: Decrease, Growth Under Development 1.92
271 Inhibition of thyroid peroxidase leading to impaired fertility in fish June-Woo Park BY-SA 279: Thyroperoxidase, Inhibition 78: Reduction, Cumulative fecundity and spawning Under Development 1.59
202 Inhibitor binding to topoisomerase II leading to infant leukaemia Andrea Terron BY-SA 1252: Binding to (interferes with) topoisomerase II enzyme 1254: Infant leukaemia WPHA/WNT Endorsed 1.53
206 Peroxisome proliferator-activated receptors γ inactivation leading to lung fibrosis Jinhee Choi BY-SA 1270: Inactivation of PPARγ 1276: Lung fibrosis Under Development 1.54
212 Histone deacetylase inhibition leading to testicular atrophy Shihori Tanabe BY-SA 1502: Histone deacetylase inhibition 1506: Testicular atrophy WPHA/WNT Endorsed 1.52
149 Peptide Oxidation Leading to Hypertension Frazer Lowe BY-SA 209: Peptide Oxidation 952: Hypertension Under Development 1.50
150 Aryl hydrocarbon receptor activation leading to early life stage mortality, via reduced VEGF Amani Farhat BY-SA 18: Activation, AhR 947: Increase, Early Life Stage Mortality WPHA/WNT Endorsed 1.7
151 AhR activation leading to preeclampsia Sabrina Tait BY-SA 18: Activation, AhR 1893: increase, Preeclampsia Under Development 1.42
152 Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity Kristie Sullivan BY-SA 957: Binding, Transthyretin in serum 402: Cognitive function, decreased Under Development 1.41
154 Inhibition of Calcineurin Activity Leading to Impaired T-Cell Dependent Antibody Response Takumi Ohishi BY-SA 980: Inhibition, Calcineurin Activity 984: Impairment, T-cell dependent antibody response WPHA/WNT Endorsed 1.38
155 Deiodinase 2 inhibition leading to increased mortality via reduced posterior swim bladder inflation Dries Knapen BY-SA 1002: Inhibition, Deiodinase 2 WPHA/WNT Endorsed 1.35
156 Deiodinase 2 inhibition leading to increased mortality via reduced anterior swim bladder inflation Dries Knapen BY-SA 1002: Inhibition, Deiodinase 2 WPHA/WNT Endorsed 1.35
157 Deiodinase 1 inhibition leading to increased mortality via reduced posterior swim bladder inflation Dries Knapen BY-SA 1009: Inhibition, Deiodinase 1 WPHA/WNT Endorsed 1.35
158 Deiodinase 1 inhibition leading to increased mortality via reduced anterior swim bladder inflation Dries Knapen BY-SA 1009: Inhibition, Deiodinase 1 WPHA/WNT Endorsed 1.35
159 Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation Dries Knapen BY-SA 279: Thyroperoxidase, Inhibition WPHA/WNT Endorsed 1.35
131 Aryl hydrocarbon receptor activation leading to uroporphyria Amani Farhat BY-SA 18: Activation, AhR 369: Uroporphyria WPHA/WNT Endorsed 1.7
136 Intracellular Acidification Induced Olfactory Epithelial Injury Leading to Site of Contact Nasal Tumors Undefined BY-SA 867: Decrease, Intracellular pH 872: Increase, Site of Contact Nasal Tumors Under Review 2.7
144 Endocytic lysosomal uptake leading to liver fibrosis Marina Kuburic BY-SA 1539: Endocytotic lysosomal uptake 344: Increase, Liver fibrosis Under Review 1.47
148 EGFR Activation Leading to Decreased Lung Function Karsta Luettich BY-SA 941: Activation, EGFR 1250: Decrease, Lung function Under Development 1.51
220 Cyp2E1 Activation Leading to Liver Cancer Francina Webster BY-SA 1391: Activation of Cyp2E1 1395: Liver Cancer WPHA/WNT Endorsed 1.24
237 Substance interaction with lung resident cell membrane components leading to atherosclerosis via acute phase response Ulla Vogel BY-SA 1495: Substance interaction with the lung resident cell membrane components 1443: Atherosclerosis Under Development 1.55