AOPs

OECD View API
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Showing 426 to 450 of 584 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
209 Perturbation of cholesterol and glutathione homeostasis leading to hepatotoxicity: Integrated multi-OMICS approach for building AOP Jinhee Choi BY-SA None 1291: Hepatotoxicity
210 Activation of c-Jun N-terminal kinase (JNK) and Forkhead box O (FOXO) and reduction of WNT pathways leading to reproductive failure: Integrated multi-OMICS approach for AOP building Jinhee Choi BY-SA None 1277: Reproductive failure
213 Inhibition of fatty acid beta oxidation leading to nonalcoholic steatohepatitis (NASH) Lyle Burgoon Open for adoption 1490: Inhibition, Fatty Acid Beta Oxidation 1489: Increase, Steatohepatitis
214 Network of SSRIs (selective serotonin reuptake inhibitors) Lyle Burgoon Open for adoption None
215 Molecular events lead to epilepsy Lyle Burgoon Open for adoption None
216 Deposition of energy leading to population decline via DNA strand breaks and follicular atresia Knut Erik Tollefsen BY-SA 1686: Deposition of Energy
217 Gastric ulcer formation Lyle Burgoon Open for adoption None
229 Helicobacter pylori to gastric ulcer Lyle Burgoon Open for adoption 1412: Helicobacter pylori infection 1385: Activated, gastric ulcer formation
219 Inhibition of CYP7B activity leads to decreased reproductive success via decreased sexual behavior Florence Pagé-Larivière BY-SA 1386: CYP7B activity, inhibition 360: Decrease, Population growth rate
221 Mental stress to depression Lyle Burgoon Open for adoption 1396: Increased, glucocorticoid receptor activity 1346: Increased, depression
222 Mental stress to agitation Lyle Burgoon Open for adoption 1396: Increased, glucocorticoid receptor activity 1345: Increased, agitation
223 Serotonin transporter activation to seizure Lyle Burgoon Open for adoption 1397: Increased, serotonin transporter activity 1344: Increased, seizure
224 Serotonin transporter activation to depression Lyle Burgoon Open for adoption 1397: Increased, serotonin transporter activity 1346: Increased, depression
225 Serotonin transporter activation to agitation Lyle Burgoon Open for adoption None 1345: Increased, agitation
226 SSRI (Selective serotonin reuptake inhibitor) to hypertension Lyle Burgoon Open for adoption 1317: Decreased, serotonin transporter activity 1343: Increase, hypertension
227 NSAID induced PTGS1 inactivation to gastric ulcer Lyle Burgoon Open for adoption 1402: Reduced, PTGS1 function 1385: Activated, gastric ulcer formation
205 AOP from chemical insult to cell death Mathieu Vinken BY-SA
196 Volatile Organic Chemicals Activate TRPA1 Receptor to Induce Sensory Pulmonary Irritation Jeanelle Martinez BY-SA 1215: TRPA1 activation, TRPA1 Receptor
200 Estrogen receptor activation leading to breast cancer Molly M Morgan Open for adoption 111: Agonism, Estrogen receptor 1193: N/A, Breast Cancer
201 Juvenile hormone receptor agonism leading to male offspring induction associated population decline Knut Erik Tollefsen BY-SA 1205: Activation, Juvenile hormone receptor
40 Covalent Protein binding leading to Skin Sensitisation Undefined BY-SA 396: Covalent Binding, Protein 827: sensitisation, skin WPHA/WNT Endorsed 1.1
42 Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals Kevin Crofton BY-SA 279: Thyroperoxidase, Inhibition 402: Cognitive function, decreased WPHA/WNT Endorsed 1.10
503 Activation of uterine estrogen receptor-alfa leading to endometrial adenocarcinoma, via epigenetic modulation Barbara Viviani BY-SA 1065: Activation, estrogen receptor alpha 2154: Uterine adenocarcinoma (endometrioid adenocarcinoma Type I) Under Review 1.100
502 Decrease, cholesterol synthesis leads to orofacial clefting Jacob Reynolds BY-SA None 2042: Increase, Orofacial clefting Under Development 1.101
491 Decrease, GLI1/2 target gene expression leads to orofacial clefting Jacob Reynolds BY-SA 2040: Decrease, GLI1/2 target gene expression 2042: Increase, Orofacial clefting Under Development 1.101