AOPs

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Showing 451 to 475 of 558 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
151 AhR activation leading to preeclampsia Sabrina Tait BY-SA 18: Activation, AhR 1893: increase, Preeclampsia Under Development 1.42
212 Histone deacetylase inhibition leading to testicular atrophy Shihori Tanabe BY-SA 1502: Histone deacetylase inhibition 1506: Testicular atrophy WPHA/WNT Endorsed 1.52
379 Binding to ACE2 leading to thrombosis and disseminated intravascular coagulation Shihori Tanabe All rights reserved 1739: Binding to ACE2 1846: Thrombosis and Disseminated Intravascular Coagulation Under Development 1.96
298 Increase in reactive oxygen species (ROS) leading to human treatment-resistant gastric cancer Shihori Tanabe BY-SA 1115: Increase, Reactive oxygen species 1651: Treatment-resistant gastric cancer Under Review 1.58
475 Binding of chemicals to ionotropic glutamate receptors leads to impairment of learning and memory via loss of drebrin from dendritic spines of neurons Shihori Tanabe All rights reserved 875: Binding of agonist, Ionotropic glutamate receptors 341: Impairment, Learning and memory Under Development 1.107
636 Increase in reactive oxygen species (ROS) leading to human amyotrophic lateral sclerosis (ALS) Shihori Tanabe All rights reserved 1115: Increase, Reactive oxygen species 2416: human amyotrophic lateral sclerosis (ALS)
202 Inhibitor binding to topoisomerase II leading to infant leukaemia Andrea Terron BY-SA 1252: Binding to (interferes with) topoisomerase II enzyme 1254: Infant leukaemia WPHA/WNT Endorsed 1.53
3 Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits Andrea Terron BY-SA 888: Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I) 896: Parkinsonian motor deficits WPHA/WNT Endorsed 1.33
457 Succinate dehydrogenase inhibition leading to increased insulin resistance through reduction in circulating thyroxine Simon Thomas Open for adoption 2118: Succinate dehydrogenase, inhibited 2119: Increase, Insulin resistance
461 Deposition of ionising energy leads to population decline via impaired oogenesis and spermatogenesis Knut Erik Tollefsen BY-SA None None
4 Ecdysone receptor agonism leading to mortality via suppression of Ftz-f1 Knut Erik Tollefsen BY-SA 103: Increase, Ecdysone receptor hyperactivation
161 Glutamate-gated chloride channel activation leading to neurotransmission inhibition associated mortality Knut Erik Tollefsen BY-SA 1018: Activation, Glutamate-gated chloride channels 351: Increased Mortality
160 Ionotropic gamma-aminobutyric acid receptor activation mediated neurotransmission inhibition leading to mortality Knut Erik Tollefsen BY-SA 762: Activation, ionotropic GABA Receptor chloride channel 351: Increased Mortality
216 Deposition of energy leading to population decline via DNA strand breaks and follicular atresia Knut Erik Tollefsen BY-SA 1686: Deposition of Energy
201 Juvenile hormone receptor agonism leading to male offspring induction associated population decline Knut Erik Tollefsen BY-SA 1205: Activation, Juvenile hormone receptor
386 Deposition of ionizing energy leading to population decline via inhibition of photosynthesis Knut Erik Tollefsen BY-SA 1686: Deposition of Energy
387 Deposition of ionising energy leading to population decline via mitochondrial dysfunction Knut Erik Tollefsen BY-SA 1686: Deposition of Energy
388 Deposition of ionising energy leading to population decline via programmed cell death Knut Erik Tollefsen BY-SA 1686: Deposition of Energy
389 Oxygen-evolving complex damage leading to population decline via inhibition of photosynthesis Knut Erik Tollefsen BY-SA 1865: Increase, Oxygen-evolving complex damage
245 Reduction in photophosphorylation leading to growth inhibition in aquatic plants Knut Erik Tollefsen BY-SA 1471: Increase, Uncoupling of photophosphorylation 1521: Decrease, Growth
238 Deposition of energy leading to population decline via DNA strand breaks and oocyte apoptosis Knut Erik Tollefsen BY-SA 1686: Deposition of Energy
12 Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging Florianne Tschudi-Monnet BY-SA 201: Binding of antagonist, NMDA receptors WPHA/WNT Endorsed 1.13
273 Mitochondrial complex inhibition leading to liver injury Wanda van der Stel BY-SA
363 Thyroperoxidase inhibition leading to altered visual function via altered retinal layer structure Lucia Vergauwen BY-SA 279: Thyroperoxidase, Inhibition Under Review 1.35
364 Thyroperoxidase inhibition leading to altered visual function via decreased eye size Lucia Vergauwen All rights reserved 279: Thyroperoxidase, Inhibition Under Development 1.35