AOPs

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Showing 451 to 475 of 584 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
460 Antagonism of Smoothened receptor leading to orofacial clefting Jacob Reynolds BY-SA 2027: Antagonism, Smoothened receptor 2042: Increase, Orofacial clefting Under Review 1.101
480 Mitochondrial complexes inhibition leading to heart failure via decreased ATP production Alexandra Schaffert BY-SA 105: Inhibition, Mitochondrial Electron Transport Chain Complexes 2215: Decrease Left Ventricular function Under Development 1.102
479 Mitochondrial complexes inhibition leading to left ventricular function decrease via increased myocardial oxidative stress Sivakumar Murugadoss BY-SA 105: Inhibition, Mitochondrial Electron Transport Chain Complexes 2215: Decrease Left Ventricular function Under Development 1.102
443 DNA damage and mutations leading to Metastatic Breast Cancer Usha Adiga BY-SA 1669: Increased, DNA damage and mutation 1982: metastatic breast cancer Under Development 1.103
440 Hypothalamus estrogen receptors activity suppression leading to ovarian cancer via ovarian epithelial cell hyperplasia Kalyan Gayen BY-SA 1046: Suppression, Estrogen receptor (ER) activity Under Development 1.104
439 Activation of the AhR leading to metastatic breast cancer Louise Benoit BY-SA 18: Activation, AhR 1982: metastatic breast cancer Under Review 1.105
474 Succinate dehydrogenase inactivation leads to cancer by promoting EMT Sylvie Bortoli BY-SA 2118: Succinate dehydrogenase, inhibited 885: Increase, Cancer Under Development 1.106
475 Binding of chemicals to ionotropic glutamate receptors leads to impairment of learning and memory via loss of drebrin from dendritic spines of neurons Shihori Tanabe All rights reserved 875: Binding of agonist, Ionotropic glutamate receptors 341: Impairment, Learning and memory Under Development 1.107
344 Androgen receptor (AR) antagonism leading to nipple retention (NR) in male (mammalian) offspring Terje Svingen BY-SA 26: Antagonism, Androgen receptor 1786: Nipple retention (NR), increased Under Development 1.108
345 Androgen receptor (AR) antagonism leading to decreased fertility in females Terje Svingen BY-SA 26: Antagonism, Androgen receptor Under Development 1.109
397 Bulky DNA adducts leading to mutations Carole Yauk BY-SA 1879: Bulky DNA adducts, increase 185: Increase, Mutations Under Development 1.11
15 Alkylation of DNA in male pre-meiotic germ cells leading to heritable mutations Carole Yauk BY-SA 97: Alkylation, DNA 336: Increase, Heritable mutations in offspring WPHA/WNT Endorsed 1.11
106 Chemical binding to tubulin in oocytes leading to aneuploid offspring Francesco Marchetti BY-SA 718: Binding, Tubulin 728: Increase, Aneuploid offspring Under Review 1.11
23 Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish) Dan Villeneuve BY-SA 25: Agonism, Androgen receptor 360: Decrease, Population growth rate WPHA/WNT Endorsed 1.12
25 Aromatase inhibition leading to reproductive dysfunction Dan Villeneuve BY-SA 36: Inhibition, Aromatase 360: Decrease, Population growth rate WPHA/WNT Endorsed 1.12
30 Estrogen receptor antagonism leading to reproductive dysfunction Dan Villeneuve BY-SA 112: Antagonism, Estrogen receptor 360: Decrease, Population growth rate Under Review 1.12
376 Androgen receptor agonism leading to male-biased sex ratio Dan Villeneuve BY-SA 25: Agonism, Androgen receptor 360: Decrease, Population growth rate WPHA/WNT Endorsed 1.12
346 Aromatase inhibition leads to male-biased sex ratio via impacts on gonad differentiation Kelvin Santana Rodriguez BY-SA 36: Inhibition, Aromatase 360: Decrease, Population growth rate WPHA/WNT Endorsed 1.12
17 Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory Marie-Gabrielle Zurich BY-SA 1487: Binding, Thiol/seleno-proteins involved in protection against oxidative stress 341: Impairment, Learning and memory WPHA/WNT Endorsed 1.13
12 Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging Florianne Tschudi-Monnet BY-SA 201: Binding of antagonist, NMDA receptors WPHA/WNT Endorsed 1.13
38 Protein Alkylation leading to Liver Fibrosis Brigitte Landesmann BY-SA 244: Alkylation, Protein 344: Increase, Liver fibrosis WPHA/WNT Endorsed 1.14
10 Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures in adult brain Ping Gong BY-SA 667: Binding at picrotoxin site, iGABAR chloride channel 613: Occurrence, Epileptic seizure WPHA/WNT Endorsed 1.15
31 Oxidation of iron in hemoglobin leading to hematotoxicity Undefined Open for adoption 213: N/A, Parent compound is converted to the reactive metabolite and forms free radicals leading to oxidation of heme iron(II) in hemoglobin to iron(III) 321: N/A, Cyanosis occurs Under Development 1.16
107 Constitutive androstane receptor activation leading to hepatocellular adenomas and carcinomas in the mouse and the rat Kristin Lichti-Kaiser BY-SA 715: Activation, Constitutive androstane receptor 719: Increase, hepatocellular adenomas and carcinomas Under Review 1.17
37 PPARĪ± activation leading to hepatocellular adenomas and carcinomas in rodents Chris Corton BY-SA 227: Activation, PPARĪ± 719: Increase, hepatocellular adenomas and carcinomas Under Development 1.17