AOPs

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Showing 451 to 475 of 591 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
491 Decrease, GLI1/2 target gene expression leads to orofacial clefting Jacob Reynolds BY-SA 2040: Decrease, GLI1/2 target gene expression 2042: Increase, Orofacial clefting Under Development 1.101
480 Mitochondrial complexes inhibition leading to heart failure via decreased ATP production Alexandra Schaffert BY-SA 105: Inhibition, Mitochondrial Electron Transport Chain Complexes 2215: Decrease Left Ventricular function Under Development 1.102
479 Mitochondrial complexes inhibition leading to left ventricular function decrease via increased myocardial oxidative stress Sivakumar Murugadoss BY-SA 105: Inhibition, Mitochondrial Electron Transport Chain Complexes 2215: Decrease Left Ventricular function Under Development 1.102
316 Trypsin inhibition leading to pancreatic acinar cell tumors Shigeru Hisada BY-SA 1720: Trypsin inhibition 1725: Pancreatic acinar cell tumors Under Development 1.60
319 Binding to ACE2 leading to lung fibrosis Young Jun Kim BY-SA 1740: Induced dysregulation of ACE2 1276: Lung fibrosis Under Development 1.96
320 Binding of SARS-CoV-2 to ACE2 receptor leading to acute respiratory distress associated mortality Young Jun Kim BY-SA 1739: Binding to ACE2 351: Increased Mortality Under Development 1.96
344 Androgen receptor (AR) antagonism leading to nipple retention (NR) in male (mammalian) offspring Terje Svingen BY-SA 26: Antagonism, Androgen receptor 1786: Nipple retention (NR), increased Under Development 1.108
345 Androgen receptor (AR) antagonism leading to decreased fertility in females Terje Svingen BY-SA 26: Antagonism, Androgen receptor Under Development 1.109
297 Inhibition of retinaldehyde dehydrogenase leads to population decline Young Jun Kim BY-SA 1637: Retinaldehyde dehydrogenase inhibition 360: Decrease, Population growth rate Under Development 1.77
300 Thyroid Receptor Antagonism and Subsequent Adverse Neurodevelopmental Outcomes in Mammals Kevin Crofton BY-SA 1656: Antagonism, Thyroid Receptor 402: Cognitive function, decreased Under Development 1.84
302 Lung surfactant function inhibition leading to decreased lung function Jorid Birkelund Sørli BY-SA 1672: Inhibition of lung surfactant function 1250: Decrease, Lung function Under Development 1.87
303 Frustrated phagocytosis-induced lung cancer Carole Seidel BY-SA 1668: Frustrated phagocytosis 1670: Lung cancer Under Development 1.86
294 Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer Jessica Helm BY-SA 1632: Increase in reactive oxygen and nitrogen species (RONS) Under Development 1.80
295 Early-life stromal estrogen receptor activation by endocrine disrupting chemicals in the mammary gland leading to enhanced cancer risk Andrea Hindman BY-SA None None Under Development 1.79
292 Inhibition of tyrosinase leads to decreased population in fish Young Jun Kim BY-SA 1627: Inhibition of tyrosinase 360: Decrease, Population growth rate Under Development 1.78
293 Increased DNA damage leading to increased risk of breast cancer Jessica Helm BY-SA 1194: Increase, DNA damage Under Development 1.80
283 L-type calcium channel blockade leading to hypotension Luigi Margiotta-Casaluci BY-SA None None Under Development 1.45
289 Inhibition of 5α-reductase leading to decreased population growth rate via impaired fecundity in female fish Young Jun Kim BY-SA 1617: Inhibition, 5α-reductase 360: Decrease, Population growth rate Under Development 1.81
313 Stimulation of TLR7/8 in dendric cells leading to Psoriatic skin disease Hiroyuki Komatsu BY-SA 1706: Stimulation, TLR7/8 1709: Psoriatic skin disease Under Development 1.75
314 Binding to estrogen receptor (ER)-α in immune cells leading to exacerbation of systemic lupus erythematosus (SLE) Yasuharu Otsubo BY-SA 1710: Binding to estrogen receptor (ER)-α in immune cells 1714: Exacerbation of systemic lupus erythematosus (SLE) Under Development 1.73
315 Inhibition of JAK3 leading to impairment of T-Cell Dependent Antibody Response Yasuhiro Yoshida BY-SA 1715: Inhibition of JAK3 1719: Impairment of T-cell dependent antibody response Under Development 1.74
474 Succinate dehydrogenase inactivation leads to cancer by promoting EMT Sylvie Bortoli BY-SA 2118: Succinate dehydrogenase, inhibited 885: Increase, Cancer Under Development 1.106
398 Decreased ALDH1A (RALDH) activity leading to decreased fertility via disrupted meiotic initiation of fetal oogonia Terje Svingen BY-SA 1880: Decreased, ALDH1A (RALDH) enzyme activity 406: decreased, Fertility Under Development 1.97
412 Endothelial cell dysfunction leading to thromboinflammation Luigi Margiotta-Casaluci BY-SA None 1916: Thromboinflammation, Increased Under Development 1.96
422 Binding of SARS-CoV-2 to ACE2 in enterocytes leads to intestinal barrier disruption Laure-Alix Clerbaux BY-SA 1739: Binding to ACE2 None Under Development 1.96