AOPs

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Showing 26 to 50 of 556 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
377 Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS) Gillina Bezemer BY-SA 1842: Prolonged TLR9 activation
378 Dysregulated underperforming Toll Like Receptors (TLRs) leading to high pathogen load Gillina Bezemer BY-SA 1848: Toll Like Receptor (TLR) Dysregulation None
403 combined unhealthy lifestyle factors leading to metabolic syndrome Gillina Bezemer BY-SA None None
404 Metabolic Syndrome leading to Toll Like Receptor dysregulation Gillina Bezemer BY-SA None None
433 hERG channel blockade leading to sudden cardiac death Egemen Bilgin BY-SA 2099: hERG channel blockade 1964: Sudden cardiac death
616 organic UV filter and its Photoproducts reproductive toxicity pathways Nataraj Bojan All rights reserved 2391: Reduced fertility / fecundity
546 Succinate dehydrogenase inactivation leads to cancer through hypoxic-like mechanisms Sylvie Bortoli BY-SA 2118: Succinate dehydrogenase, inhibited 885: Increase, Cancer
474 Succinate dehydrogenase inactivation leads to cancer by promoting EMT Sylvie Bortoli BY-SA 2118: Succinate dehydrogenase, inhibited 885: Increase, Cancer Under Development 1.106
543 Inhibition of neuropathy target esterase leading to delayed neuropathy via lysolecithin cell membrane integration Brooke Bowe BY-SA 2262: Neuropathy target esterase, inhibited 2267: Delayed neuropathy, increased
544 Inhibition of neuropathy target esterase leading to delayed neuropathy via increased inflammation Brooke Bowe BY-SA 2262: Neuropathy target esterase, inhibited 2267: Delayed neuropathy, increased
432 Deposition of Energy by Ionizing Radiation leading to Acute Myeloid Leukemia Dag Anders Brede BY-SA 1686: Deposition of Energy 1955: Acute Myeloid Leukemia
540 Oxidative Stress in the Fish Ovary Leads to Reproductive Impairment via Reduced Vitellogenin Production Kevin Brix BY-SA 1115: Increase, Reactive oxygen species 360: Decrease, Population growth rate
260 CYP2E1 activation and formation of protein adducts leading to neurodegeneration Jelle Broeders BY-SA 1514: Neurodegeneration
229 Helicobacter pylori to gastric ulcer Lyle Burgoon Open for adoption 1412: Helicobacter pylori infection 1385: Activated, gastric ulcer formation
230 presynaptic neuron 1 activation to epilepsy Lyle Burgoon Open for adoption 1349: Activated, presynaptic neuron 1 1363: Increased, epilepsy
231 presynaptic neuron 2 repression to epilepsy Lyle Burgoon Open for adoption 1413: Reduced, presynaptic neuron 2 activity 1363: Increased, epilepsy
232 NFE2/Nrf2 repression to steatosis Lyle Burgoon Open for adoption 1417: NFE2/Nrf2 repression 459: Increase, Liver steatosis
228 NSAID induced PTGS2 inactivation to gastric ulcer Lyle Burgoon Open for adoption 1408: Reduced, PTGS2 function 1385: Activated, gastric ulcer formation
26 Calcium-mediated neuronal ROS production and energy imbalance Lyle Burgoon Open for adoption 51: Inhibition, Ca++ ATPase 1392: Increase, Oxidative Stress
215 Molecular events lead to epilepsy Lyle Burgoon Open for adoption None
227 NSAID induced PTGS1 inactivation to gastric ulcer Lyle Burgoon Open for adoption 1402: Reduced, PTGS1 function 1385: Activated, gastric ulcer formation
226 SSRI (Selective serotonin reuptake inhibitor) to hypertension Lyle Burgoon Open for adoption 1317: Decreased, serotonin transporter activity 1343: Increase, hypertension
225 Serotonin transporter activation to agitation Lyle Burgoon Open for adoption None 1345: Increased, agitation
224 Serotonin transporter activation to depression Lyle Burgoon Open for adoption 1397: Increased, serotonin transporter activity 1346: Increased, depression
223 Serotonin transporter activation to seizure Lyle Burgoon Open for adoption 1397: Increased, serotonin transporter activity 1344: Increased, seizure