AOPs

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Showing 26 to 50 of 581 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
507 Nrf2 inhibition leading to vascular disrupting effects via inflammation pathway Yanhong Wei BY-SA 1417: NFE2/Nrf2 repression 2161: Increase, Vascular disrupting effects
508 Nrf2 inhibition leading to vascular disrupting effects through activating HIF1α, Semaphorin 6A, and Dll4-Notch pathway Yanhong Wei BY-SA 1417: NFE2/Nrf2 repression 2161: Increase, Vascular disrupting effects
509 Nrf2 inhibition leading to vascular disrupting effects through activating apoptosis signal pathway and mitochondrial dysfunction Yanhong Wei BY-SA 1417: NFE2/Nrf2 repression 2161: Increase, Vascular disrupting effects
510 Demethylation of PPAR promotor leading to vascular disrupting effects Yanhong Wei BY-SA 228: peroxisome proliferator activated receptor promoter demethylation 2161: Increase, Vascular disrupting effects
511 The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects Yanhong Wei BY-SA 1115: Increase, Reactive oxygen species 2161: Increase, Vascular disrupting effects
512 Reduced availability of GnRH leading to uterine adenocarcinoma via increased estrogen availability at target organ level Ana-Andreea Cioca BY-SA None None
513 Reactive Oxygen (ROS) formation leads to cancer via Peroxisome proliferation-activated receptor (PPAR) pathway John Frisch BY-SA 1115: Increase, Reactive oxygen species 885: Increase, Cancer
514 PLK1 Activation leading to hepatocyte apoptosis-associate liver injury via autophagy-mediated excessive COX6A1 degradation and impaired function of mitochondrial respiratory chain complex IV Hui Li BY-SA None None
515 An overview of adverse outcome pathway linked between PM2.5 exposure and congenital heart defects Liang Chen BY-SA None None
516 Na+ /K+ -ATPase inhibition leading to hypertension Michelle Angrish BY-SA 1562: Decreased Na/K ATPase activity 952: Hypertension
517 Pregnane X Receptor (PXR) activation leads to liver steatosis John Frisch BY-SA 239: Activation, Pregnane-X receptor, NR1I2 459: Increase, Liver steatosis
518 Liver X Receptor (LXR) activation leads to liver steatosis John Frisch BY-SA 167: Activation, LXR 459: Increase, Liver steatosis
478 Deposition of energy leading to occurrence of cataracts Vinita Chauhan BY-SA 1686: Deposition of Energy 2083: Occurrence of Cataracts WPHA/WNT Endorsed 1.89
481 AOPs of amorphous silica nanoparticles: ROS-mediated oxidative stress increased respiratory dysfunction and diseases. Hailin Xu BY-SA 1115: Increase, Reactive oxygen species
482 Deposition of energy leading to occurrence of bone loss Vinita Chauhan BY-SA 1686: Deposition of Energy 2091: Occurrence, Bone Loss WPHA/WNT Endorsed 1.89
483 Deposition of Energy Leading to Learning and Memory Impairment Vinita Chauhan BY-SA 1686: Deposition of Energy 341: Impairment, Learning and memory WPHA/WNT Endorsed 1.89
484 Bisphenol A analogs induce cellular dysfunction in human trophoblast cells in a thyroid hormone receptor-dependent manner: in silico and in vitro analyses Xiaoyun Wu BY-SA None None
485 Thyroid hormone antagonism leading to impaired oligodendrocyte maturation during development and subsequent decreased cognition Eliska Kuchovska BY-SA 1656: Antagonism, Thyroid Receptor 402: Cognitive function, decreased
486 Binding to the extracellular protein laminin leading to decreased cognitive function Eliska Kuchovska BY-SA 2109: Binding, extracellular matrix protein laminin 402: Cognitive function, decreased
487 Unknown MIE altering cholesterol metabolism leading to decreased cognition Eliska Kuchovska BY-SA 1114: Unknown, MIE 402: Cognitive function, decreased
488 Increased reactive oxygen species production leading to decreased cognitive function Eliska Kuchovska BY-SA 1115: Increase, Reactive oxygen species 402: Cognitive function, decreased
489 Inhibition of voltage-gated sodium channels leading to decreased cognition Lidwina Gerner BY-SA 1353: Binding to voltage-gated sodium channel 402: Cognitive function, decreased
490 Co-activation of IP3R and RyR leads to reduced IQ and increased socio-economic burden through non-cholinergic mechanisms Karine Audouze BY-SA
492 Glutathione conjugation leading to reproductive dysfunction via oxidative stress Leonardo Vieira BY-SA 2131: Conjugation, GSH 406: decreased, Fertility
493 ERa inactivation alters AT expansion and functions and leads to insulin resistance and metabolically unhealthy obesity Min Ji Kim BY-SA 2126: Estrogen receptor alpha inactivation 2129: Metabolically unhealthy Obesity