AOPs

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Showing 476 to 500 of 584 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
27 Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11) Mathieu Vinken BY-SA 41: Inhibition, Bile Salt Export Pump (ABCB11) 357: Cholestasis, Pathology Under Development 1.19
35 Narcosis leading to respiratory failure Dries Knapen BY-SA 46: Accumulation, Biological membranes None Under Development 1.2
39 Covalent Binding, Protein, leading to Increase, Allergic Respiratory Hypersensitivity Response Jessica Ponder BY-SA 396: Covalent Binding, Protein 313: Increase, Allergic Respiratory Hypersensitivity Response Under Development 1.20
18 PPARα activation in utero leading to impaired fertility in males Elise Grignard BY-SA 227: Activation, PPARα Under Review 1.21
51 PPARα activation leading to impaired fertility in adult male rodents Elise Grignard BY-SA 227: Activation, PPARα 406: decreased, Fertility Under Development 1.21
7 Aromatase (Cyp19a1) reduction leading to impaired fertility in adult female Elise Grignard BY-SA 408: reduction in ovarian granulosa cells, Aromatase (Cyp19a1) Under Review 1.21
13 Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities Anna Price BY-SA 201: Binding of antagonist, NMDA receptors 341: Impairment, Learning and memory WPHA/WNT Endorsed 1.22
48 Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment. Anna Price BY-SA 875: Binding of agonist, Ionotropic glutamate receptors 341: Impairment, Learning and memory WPHA/WNT Endorsed 1.23
220 Cyp2E1 Activation Leading to Liver Cancer Francina Webster BY-SA 1391: Activation of Cyp2E1 1395: Liver Cancer WPHA/WNT Endorsed 1.24
117 Androgen receptor activation leading to hepatocellular adenomas and carcinomas (in mouse and rat) Charles Wood Open for adoption 25: Agonism, Androgen receptor 719: Increase, hepatocellular adenomas and carcinomas Under Development 1.26
21 Aryl hydrocarbon receptor activation leading to early life stage mortality, via increased COX-2 Markus Hecker BY-SA 18: Activation, AhR None WPHA/WNT Endorsed 1.27
455 Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced impeded craniofacial development Prarthana Shankar BY-SA 18: Activation, AhR WPHA/WNT Endorsed 1.27
456 Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced cardiovascular toxicity Prarthana Shankar BY-SA 18: Activation, AhR 947: Increase, Early Life Stage Mortality WPHA/WNT Endorsed 1.27
54 Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment Anna Price BY-SA 424: Inhibition, Na+/I- symporter (NIS) 341: Impairment, Learning and memory WPHA/WNT Endorsed 1.28
16 Acetylcholinesterase inhibition leading to acute mortality Dan Villeneuve BY-SA 12: Acetylcholinesterase (AchE) Inhibition Under Development 1.3
187 Anticoagulant rodenticide inhibition of vitamin K epoxide reductase resulting coagulopathy and hemorrhage Undefined BY-SA 1136: Impaired recruitment , Population trajectory Under Development 1.31
173 Substance interaction with the pulmonary resident cell membrane components leading to pulmonary fibrosis Sabina Halappanavar BY-SA 1495: Substance interaction with the lung resident cell membrane components 1458: Pulmonary fibrosis WPHA/WNT Endorsed 1.32
3 Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits Andrea Terron BY-SA 888: Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I) 896: Parkinsonian motor deficits WPHA/WNT Endorsed 1.33
363 Thyroperoxidase inhibition leading to altered visual function via altered retinal layer structure Lucia Vergauwen BY-SA 279: Thyroperoxidase, Inhibition Under Review 1.35
364 Thyroperoxidase inhibition leading to altered visual function via decreased eye size Lucia Vergauwen All rights reserved 279: Thyroperoxidase, Inhibition Under Development 1.35
365 Thyroperoxidase inhibition leading to altered visual function via altered photoreceptor patterning Lucia Vergauwen All rights reserved 279: Thyroperoxidase, Inhibition Under Development 1.35
155 Deiodinase 2 inhibition leading to increased mortality via reduced posterior swim bladder inflation Dries Knapen BY-SA 1002: Inhibition, Deiodinase 2 WPHA/WNT Endorsed 1.35
156 Deiodinase 2 inhibition leading to increased mortality via reduced anterior swim bladder inflation Dries Knapen BY-SA 1002: Inhibition, Deiodinase 2 WPHA/WNT Endorsed 1.35
157 Deiodinase 1 inhibition leading to increased mortality via reduced posterior swim bladder inflation Dries Knapen BY-SA 1009: Inhibition, Deiodinase 1 WPHA/WNT Endorsed 1.35
158 Deiodinase 1 inhibition leading to increased mortality via reduced anterior swim bladder inflation Dries Knapen BY-SA 1009: Inhibition, Deiodinase 1 WPHA/WNT Endorsed 1.35