AOPs

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Showing 526 to 550 of 584 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
21 Aryl hydrocarbon receptor activation leading to early life stage mortality, via increased COX-2 Markus Hecker BY-SA 18: Activation, AhR None WPHA/WNT Endorsed 1.27
23 Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish) Dan Villeneuve BY-SA 25: Agonism, Androgen receptor 360: Decrease, Population growth rate WPHA/WNT Endorsed 1.12
25 Aromatase inhibition leading to reproductive dysfunction Dan Villeneuve BY-SA 36: Inhibition, Aromatase 360: Decrease, Population growth rate WPHA/WNT Endorsed 1.12
27 Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11) Mathieu Vinken BY-SA 41: Inhibition, Bile Salt Export Pump (ABCB11) 357: Cholestasis, Pathology Under Development 1.19
30 Estrogen receptor antagonism leading to reproductive dysfunction Dan Villeneuve BY-SA 112: Antagonism, Estrogen receptor 360: Decrease, Population growth rate Under Review 1.12
35 Narcosis leading to respiratory failure Dries Knapen BY-SA 46: Accumulation, Biological membranes None Under Development 1.2
38 Protein Alkylation leading to Liver Fibrosis Brigitte Landesmann BY-SA 244: Alkylation, Protein 344: Increase, Liver fibrosis WPHA/WNT Endorsed 1.14
39 Covalent Binding, Protein, leading to Increase, Allergic Respiratory Hypersensitivity Response Jessica Ponder BY-SA 396: Covalent Binding, Protein 313: Increase, Allergic Respiratory Hypersensitivity Response Under Development 1.20
40 Covalent Protein binding leading to Skin Sensitisation Undefined BY-SA 396: Covalent Binding, Protein 827: sensitisation, skin WPHA/WNT Endorsed 1.1
41 Sustained AhR Activation leading to Rodent Liver Tumours Undefined BY-SA 165: Activation, Long term AHR receptor driven direct and indirect gene expression changes 856: Formation, Hepatocellular and Bile duct tumors Under Review 1.7
37 PPARα activation leading to hepatocellular adenomas and carcinomas in rodents Chris Corton BY-SA 227: Activation, PPARα 719: Increase, hepatocellular adenomas and carcinomas Under Development 1.17
17 Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory Marie-Gabrielle Zurich BY-SA 1487: Binding, Thiol/seleno-proteins involved in protection against oxidative stress 341: Impairment, Learning and memory WPHA/WNT Endorsed 1.13
18 PPARα activation in utero leading to impaired fertility in males Elise Grignard BY-SA 227: Activation, PPARα Under Review 1.21
54 Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment Anna Price BY-SA 424: Inhibition, Na+/I- symporter (NIS) 341: Impairment, Learning and memory WPHA/WNT Endorsed 1.28
106 Chemical binding to tubulin in oocytes leading to aneuploid offspring Francesco Marchetti BY-SA 718: Binding, Tubulin 728: Increase, Aneuploid offspring Under Review 1.11
107 Constitutive androstane receptor activation leading to hepatocellular adenomas and carcinomas in the mouse and the rat Kristin Lichti-Kaiser BY-SA 715: Activation, Constitutive androstane receptor 719: Increase, hepatocellular adenomas and carcinomas Under Review 1.17
128 Kidney dysfunction by decreased thyroid hormone Jung-Hwa Oh BY-SA 277: Thyroid hormone synthesis, Decreased 814: Occurrence, Kidney toxicity Under Development 1.40
130 Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity Jung-Hwa Oh BY-SA 828: Inhibition, Phospholipase A 840: Formation, Liver fibrosis Under Development 1.39
117 Androgen receptor activation leading to hepatocellular adenomas and carcinomas (in mouse and rat) Charles Wood Open for adoption 25: Agonism, Androgen receptor 719: Increase, hepatocellular adenomas and carcinomas Under Development 1.26
31 Oxidation of iron in hemoglobin leading to hematotoxicity Undefined Open for adoption 213: N/A, Parent compound is converted to the reactive metabolite and forms free radicals leading to oxidation of heme iron(II) in hemoglobin to iron(III) 321: N/A, Cyanosis occurs Under Development 1.16
532 Retinoic acid receptor agonism during cerebellar development leading to impaired locomotor function Diana Lupu Open for adoption 2201: Agonism, Retinoic acid receptor 2231: Locomotor function. Impaired
533 Retinoic acid receptor antagonism during neurodevelopment leading to impaired learning and memory Diana Lupu Open for adoption 2232: Antagonism, Retinoic acid receptors 341: Impairment, Learning and memory
551 Increased Muscarinic M2 Receptor leading to Arrhythmia Young Jun Kim Open for adoption 1602: Increased Muscarinic Acetylcholine Receptors 1106: Occurrence, cardiac arrhythmia
519 Cardiac ion channels blockade leading to increased incidence of cardiovascular morbidity and mortality Young Jun Kim Open for adoption 2282: Cardiac ion channels blockade 1929: Increased incidence of cardiovascular morbidity and mortality in the general population
520 Retinoic acid receptor agonism during neurodevelopment leading to impaired learning and memory Diana Lupu Open for adoption 2201: Agonism, Retinoic acid receptor 341: Impairment, Learning and memory