AOPs

OECD View API
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Showing 51 to 75 of 555 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
222 Mental stress to agitation Lyle Burgoon Open for adoption 1396: Increased, glucocorticoid receptor activity 1345: Increased, agitation
221 Mental stress to depression Lyle Burgoon Open for adoption 1396: Increased, glucocorticoid receptor activity 1346: Increased, depression
217 Gastric ulcer formation Lyle Burgoon Open for adoption None
214 Network of SSRIs (selective serotonin reuptake inhibitors) Lyle Burgoon Open for adoption None
213 Inhibition of fatty acid beta oxidation leading to nonalcoholic steatohepatitis (NASH) Lyle Burgoon Open for adoption 1490: Inhibition, Fatty Acid Beta Oxidation 1489: Increase, Steatohepatitis
577 AhR activation leading to endometriosis Léna CAUDAL BY-SA 18: Activation, AhR None
470 Deposition of energy leads to abnormal vascular remodeling Vinita Chauhan BY-SA 1686: Deposition of Energy 2069: Occurrence, Abnormal Vascular Remodeling WPHA/WNT Endorsed 1.89
483 Deposition of Energy Leading to Learning and Memory Impairment Vinita Chauhan BY-SA 1686: Deposition of Energy 341: Impairment, Learning and memory WPHA/WNT Endorsed 1.89
482 Deposition of energy leading to occurrence of bone loss Vinita Chauhan BY-SA 1686: Deposition of Energy 2091: Occurrence, Bone Loss WPHA/WNT Endorsed 1.89
478 Deposition of energy leading to occurrence of cataracts Vinita Chauhan BY-SA 1686: Deposition of Energy 2083: Occurrence of Cataracts WPHA/WNT Endorsed 1.89
272 Deposition of energy leading to lung cancer Vinita Chauhan BY-SA 1686: Deposition of Energy 1556: Increase, lung cancer WPHA/WNT Endorsed 1.56
515 An overview of adverse outcome pathway linked between PM2.5 exposure and congenital heart defects Liang Chen BY-SA None None
206 Peroxisome proliferator-activated receptors γ inactivation leading to lung fibrosis Jinhee Choi BY-SA 1270: Inactivation of PPARγ 1276: Lung fibrosis Under Development 1.54
210 Activation of c-Jun N-terminal kinase (JNK) and Forkhead box O (FOXO) and reduction of WNT pathways leading to reproductive failure: Integrated multi-OMICS approach for AOP building Jinhee Choi BY-SA None 1277: Reproductive failure
209 Perturbation of cholesterol and glutathione homeostasis leading to hepatotoxicity: Integrated multi-OMICS approach for building AOP Jinhee Choi BY-SA None 1291: Hepatotoxicity
208 Janus kinase (JAK)/Signal transducer and activator of transcription (STAT) and Transforming growth factor (TGF)-beta pathways activation leading to reproductive failure Jinhee Choi BY-SA None 1277: Reproductive failure
207 NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans Jinhee Choi BY-SA 1174: Activation, NADPH Oxidase 1277: Reproductive failure
512 Reduced availability of GnRH leading to uterine adenocarcinoma via increased estrogen availability at target organ level Ana-Andreea Cioca BY-SA None None
530 Endocytotic lysosomal uptake leads to intestinal barrier disruption Laure-Alix Clerbaux BY-SA 1539: Endocytotic lysosomal uptake 1931: Intestinal barrier, disruption
468 Binding of SARS-CoV-2 to ACE2 leads to hyperinflammation (via cell death) Laure-Alix Clerbaux BY-SA 1739: Binding to ACE2 1868: Hyperinflammation
422 Binding of SARS-CoV-2 to ACE2 in enterocytes leads to intestinal barrier disruption Laure-Alix Clerbaux BY-SA 1739: Binding to ACE2 None Under Development 1.96
428 Binding of S-protein to ACE2 in enterocytes induces ACE2 dysregulation leading to gut dysbiosis Laure-Alix Clerbaux BY-SA 1739: Binding to ACE2 None Under Development 1.96
394 SARS-CoV-2 infection of olfactory epithelium leading to impaired olfactory function (short-term anosmia) Sandra Coecke BY-SA 1739: Binding to ACE2 1873: impaired olfactory function (anosmia) Under Development 1.96
334 Glucocorticoid Receptor Agonism Leading to Impaired Fin Regeneration Alexander Cole BY-SA 122: Increase, Glucocorticoid receptor activation 360: Decrease, Population growth rate
288 Inhibition of 17α-hydrolase/C 10,20-lyase (Cyp17A1) activity leads to birth reproductive defects (cryptorchidism) in male (mammals) Bérénice COLLET BY-SA 1609: Inhibition, Cytochrome P450 enzyme (CYP17A1) activity 1616: Malformation, cryptorchidism - maldescended testis