AOPs

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Showing 51 to 75 of 581 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
470 Deposition of energy leads to abnormal vascular remodeling Vinita Chauhan BY-SA 1686: Deposition of Energy 2069: Occurrence, Abnormal Vascular Remodeling WPHA/WNT Endorsed 1.89
471 Neuron defect induced early behavioral change Woo-Keun Kim BY-SA 2195: Increase, CNS Neural cell death
472 DNA adduct formation leading to kidney failure Manoe Janssen BY-SA 373: Formation, Pro-mutagenic DNA Adducts 759: Increased, Kidney Failure
473 Energy deposition from internalized Ra-226 decay lower oxygen binding capacity of hemocyanin Danielle Beaton BY-SA 1686: Deposition of Energy
476 Adverse Outcome Pathways diagram related to PBDEs associated male reproductive toxicity Yue Zhang BY-SA
477 Androgen receptor (AR) antagonism leading to hypospadias in male (mammalian) offspring Terje Svingen BY-SA 26: Antagonism, Androgen receptor 2082: Hypospadias, increased
521 Essential element imbalance leads to reproductive failure via oxidative stress Travis Karschnik BY-SA 2205: Increased, essential element imbalance 2147: Decreased, Viable Offspring
524 Gluten-driven immune activation leading to celiac disease in genetically predisposed individuals Antonio Fernandez Dumont BY-SA 2257: Celiac disease Under Review 1.98
526 Decreased, Chicken Ovalbumin Upstream Promoter Transcription Factor II (COUP-TFII) leads to Impaired, Spermatogenesis John Frisch BY-SA None 1758: Impaired, Spermatogenesis
527 Decreased, Chicken Ovalbumin Upstream Promoter Transcription Factor II (COUP-TFII) leads to Hypospadias, increased John Frisch BY-SA None 2082: Hypospadias, increased
494 AhR activation leading to liver fibrosis Xavier COUMOUL BY-SA 18: Activation, AhR 344: Increase, Liver fibrosis
495 Androgen receptor activation leading to prostate cancer Jianxiang Li BY-SA 25: Agonism, Androgen receptor 2135: Prostate cancer
496 Androgen receptor agonism leading to reproduction dysfunction （in zebrafish） Hongling Liu BY-SA 25: Agonism, Androgen receptor 442: Decreased, Population trajectory
497 ERa inactivation alters mitochondrial functions and insulin signalling in skeletal muscle and leads to insulin resistance and metabolic syndrome Min Ji Kim BY-SA 2126: Estrogen receptor alpha inactivation
499 Activation of MEK-ERK1/2 leads to deficits in learning and cognition via disrupted neurotransmitter release Travis Karschnik BY-SA 2146: Activation of mitogen-activated protein kinase kinase, extracellular signal-regulated kinase 1/2 341: Impairment, Learning and memory
500 Activation of MEK-ERK1/2 leads to deficits in learning and cognition via ROS and apoptosis Travis Karschnik BY-SA 2146: Activation of mitogen-activated protein kinase kinase, extracellular signal-regulated kinase 1/2 341: Impairment, Learning and memory
503 Activation of uterine estrogen receptor-alfa leading to endometrial adenocarcinoma, via epigenetic modulation Barbara Viviani BY-SA 1065: Activation, estrogen receptor alpha 2154: Uterine adenocarcinoma (endometrioid adenocarcinoma Type I) Under Review 1.100
504 SULT1E1 inhibition leading to uterine adenocarcinoma via increased estrogen availability at target organ level Martina Panzarea BY-SA 2155: Inhibition of Sulfotransferase E1 (SULT1E1) 1065: Activation, estrogen receptor alpha
596 Excessive reactive oxygen species leading to growth inhibition via protein oxidation and cell injury/death You Song BY-SA 1115: Increase, Reactive oxygen species 1521: Decrease, Growth
605 Thyroid Peroxidase Inhibition Leading to Reduced, Swimming Performance via Hypomyelination Ki-Tae Kim BY-SA 279: Thyroperoxidase, Inhibition
603 Excessive reactive oxygen species leading to growth inhibition via protein oxidation and cell cycle disruption You Song BY-SA 1115: Increase, Reactive oxygen species 1521: Decrease, Growth
602 Excessive reactive oxygen species leading to growth inhibition via oxidative DNA damage You Song BY-SA 1115: Increase, Reactive oxygen species 1521: Decrease, Growth
601 Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and reduced cell proliferation You Song BY-SA 1115: Increase, Reactive oxygen species 1521: Decrease, Growth
600 Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and reduced cell growth You Song BY-SA 1115: Increase, Reactive oxygen species 1521: Decrease, Growth
599 Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and cell injury/death You Song BY-SA 1115: Increase, Reactive oxygen species 1521: Decrease, Growth