AOPs

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Showing 51 to 75 of 581 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
114 HPPD inhibition leading to corneal papillomas and carcinomas (in rat) Charles Wood BY-SA 766: Inhibition, 4-hydroxyphenyl-pyruvate dioxygenase (HPPD) enzyme 779: Increase, Papillomas/carcinomas (squamous cells)
113 Glutamate-gated chloride channel activation leading to acute mortality Helen Poynton BY-SA 760: Activation, Glutamate-gated chloride channel
112 Increased dopaminergic activity leading to endometrial adenocarcinomas (in Wistar rat) Charles Wood BY-SA 746: Increase, Dopaminergic activity 773: Increase, Endometrial adenocarcinomas
111 Decrease in androgen receptor activity leading to Leydig cell tumors (in rat) Charles Wood BY-SA 1614: Decrease, androgen receptor activation 745: Increase, Leydig cell tumors
110 Inhibition of iodide pump activity leading to follicular cell adenomas and carcinomas (in rat and mouse) Charles Wood BY-SA 424: Inhibition, Na+/I- symporter (NIS) 741: Increase, Adenomas/carcinomas (follicular cell)
90 Nicotinic acetylcholine receptor activation contributes to abnormal roll change within the worker bee caste leading to colony loss/failure 2 Carlie LaLone BY-SA 559: Activation, Nicotinic acetylcholine receptor
73 Xenobiotic Inhibition of Dopamine-beta-Hydroxylase and subsequent reduced fecundity Undefined BY-SA 526: Inhibition, Inhibition of Dopamine-beta-hydroxylase 527: Decreased, Decreased fecundity
74 Modulation of Adult Leydig Cell Function Subsequent to Hypermethylation in the Fetal Testis Undefined BY-SA 662: Decreased testosterone by the fetal Leydig cells, Hypermethylation in the fetal testis 543: Decreased fertility in the adult, Decreased sperm quantity and/or quality in the adult testis
77 Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony death/failure 1 Carlie LaLone BY-SA 559: Activation, Nicotinic acetylcholine receptor 563: Death/Failure, Colony
78 Nicotinic acetylcholine receptor activation contributes to abnormal role change within the worker bee caste leading to colony death failure 1 Carlie LaLone BY-SA 559: Activation, Nicotinic acetylcholine receptor
79 Nicotinic acetylcholine receptor activation contributes to impaired hive thermoregulation and leads to colony loss/failure Carlie LaLone BY-SA 559: Activation, Nicotinic acetylcholine receptor 563: Death/Failure, Colony
80 Nicotinic acetylcholine receptor activation contributes to accumulation of damaged mitochondrial DNA and leads to colony loss/failure Carlie LaLone BY-SA 559: Activation, Nicotinic acetylcholine receptor
81 Increased metabolic stress contributes to abnormal foraging and leads to colony loss/failure Carlie LaLone BY-SA None
82 Abnormal role change in worker caste contributes to reduced brood care and leads to colony loss/failure Carlie LaLone BY-SA None
84 Suppression of immune system contributes to impaired development and leads to colony loss/failure Carlie LaLone BY-SA None
85 Suppression of immune system contributes to abnormal foraging and leads to colony loss/failure Carlie LaLone BY-SA None
86 Decrease Glucose oxidase activity contributes to reduction of antiseptic in food and leads to colony loss/failure Carlie LaLone BY-SA None
87 Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure Carlie LaLone BY-SA 559: Activation, Nicotinic acetylcholine receptor 563: Death/Failure, Colony
88 Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure via abnormal role change within caste Carlie LaLone BY-SA 559: Activation, Nicotinic acetylcholine receptor 563: Death/Failure, Colony
89 Nicotinic acetylcholine receptor activation followed by desensitization contributes to abnormal foraging and directly leads to colony loss/failure Carlie LaLone BY-SA 559: Activation, Nicotinic acetylcholine receptor 563: Death/Failure, Colony
72 Epigenetic modification of PPARG leading to adipogenesis Michelle Angrish BY-SA 1447: obesity
91 Sodium channel inhibition leading to reduced survival Kellie Fay BY-SA 584: Inhibition, sodium channel
93 sodium channel inhibition leading to increased predation Kellie Fay BY-SA 584: Inhibition, sodium channel 588: Increased, predation
94 Sodium channel inhibition leading to congenital malformations Kellie Fay BY-SA 584: Inhibition, sodium channel 591: Increased, amputations
95 Ether-a-go-go (ERG) voltage-gated potassium channel inhibition leading to reduced survival Kellie Fay BY-SA 593: Inhibition, Ether-a-go-go (ERG) voltage-gated potassium channel 592: Reduced, survival