AOPs

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Showing 51 to 75 of 581 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
126 Alpha-noradrenergic antagonism leads to reduced fecundity via delayed ovulation Undefined BY-SA 849: Inhibition, Antgonism of NE receptor 527: Decreased, Decreased fecundity
124 HMG-CoA reductase inhibition leading to decreased fertility Kellie Fay BY-SA 804: Inhibition, HMG-CoA reductase 330: Decrease, Fertility
123 Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription Dalma Martinovic-Weigelt BY-SA 801: modulation, Unknown
109 Cytotoxicity leading to bronchioloalveolar adenomas and carcinomas (in mouse) Charles Wood BY-SA 770: Increase, Cytotoxicity (club cells) 736: Increase, Adenomas/carcinomas (bronchioloalveolar)
121 Urinary bladder calculi leading to urothelial papillomas and carcinomas (in mouse and rat) Charles Wood BY-SA 793: Increase, Urinary bladder calculi 797: Increase, Adenomas/carcinomas (urothelial)
120 Inhibition of 5α-reductase leading to Leydig cell tumors (in rat) Charles Wood BY-SA 1617: Inhibition, 5α-reductase 745: Increase, Leydig cell tumors
119 Inhibition of thyroid peroxidase leading to follicular cell adenomas and carcinomas (in rat and mouse) Charles Wood BY-SA 279: Thyroperoxidase, Inhibition 741: Increase, Adenomas/carcinomas (follicular cell)
118 Chronic cytotoxicity leading to hepatocellular adenomas and carcinomas (in mouse and rat) Charles Wood BY-SA 786: Increase, Cytotoxicity (hepatocytes) 719: Increase, hepatocellular adenomas and carcinomas
116 Cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat) Charles Wood BY-SA 783: Increase, Cytotoxicity (tubular epithelial cells) 713: Increase, Adenomas/carcinomas (renal tubular)
115 Epithelial cytotoxicity leading to forestomach tumors (in mouse and rat) Charles Wood BY-SA 780: Increase, Cytotoxicity (epithelial cells) 779: Increase, Papillomas/carcinomas (squamous cells)
114 HPPD inhibition leading to corneal papillomas and carcinomas (in rat) Charles Wood BY-SA 766: Inhibition, 4-hydroxyphenyl-pyruvate dioxygenase (HPPD) enzyme 779: Increase, Papillomas/carcinomas (squamous cells)
113 Glutamate-gated chloride channel activation leading to acute mortality Helen Poynton BY-SA 760: Activation, Glutamate-gated chloride channel
112 Increased dopaminergic activity leading to endometrial adenocarcinomas (in Wistar rat) Charles Wood BY-SA 746: Increase, Dopaminergic activity 773: Increase, Endometrial adenocarcinomas
111 Decrease in androgen receptor activity leading to Leydig cell tumors (in rat) Charles Wood BY-SA 1614: Decrease, androgen receptor activation 745: Increase, Leydig cell tumors
110 Inhibition of iodide pump activity leading to follicular cell adenomas and carcinomas (in rat and mouse) Charles Wood BY-SA 424: Inhibition, Na+/I- symporter (NIS) 741: Increase, Adenomas/carcinomas (follicular cell)
194 Hepatic nuclear receptor activation leading to altered amphibian metamorphosis Jonathan Haselman BY-SA 1157: Activation, Hepatic nuclear receptor(s) 1101: Altered, Amphibian metamorphosis
185 Queen egg-laying decrease leads to colony loss/failure Carlie LaLone BY-SA None 563: Death/Failure, Colony
186 unknown MIE leading to renal failure and mortality Kellie Fay BY-SA 1114: Unknown, MIE 351: Increased Mortality
188 Iodotyrosine deiodinase (IYD) inhibition leading to altered amphibian metamorphosis Jonathan Haselman BY-SA 1152: Inhibition, Iodotyrosine deiodinase (IYD) 1101: Altered, Amphibian metamorphosis
189 Type I iodothyronine deiodinase (DIO1) inhibition leading to altered amphibian metamorphosis Jonathan Haselman BY-SA 1009: Inhibition, Deiodinase 1 1101: Altered, Amphibian metamorphosis
190 Type II iodothyronine deiodinase (DIO2) inhibition leading to altered amphibian metamorphosis Jonathan Haselman BY-SA 1002: Inhibition, Deiodinase 2 1101: Altered, Amphibian metamorphosis
191 Type III iodotyrosine deiodinase (DIO3) inhibition leading to altered amphibian metamorphosis Jonathan Haselman BY-SA 1153: Inhibition, Deiodinase 3 1101: Altered, Amphibian metamorphosis
192 Pendrin inhibition leading to altered amphibian metamorphosis Jonathan Haselman BY-SA 1155: Inhibition, Pendrin 1101: Altered, Amphibian metamorphosis
193 Dual oxidase (DUOX) inhibition leading to altered amphibian metamorphosis Jonathan Haselman BY-SA 1156: Inhibition, Dual oxidase 1101: Altered, Amphibian metamorphosis
184 Nosema infection causes abnormal role change that leads to colony loss/failure Carlie LaLone BY-SA None 563: Death/Failure, Colony