AOPs

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Showing 76 to 100 of 555 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
37 PPARĪ± activation leading to hepatocellular adenomas and carcinomas in rodents Chris Corton BY-SA 227: Activation, PPARĪ± 719: Increase, hepatocellular adenomas and carcinomas Under Development 1.17
494 AhR activation leading to liver fibrosis Xavier COUMOUL BY-SA 18: Activation, AhR 344: Increase, Liver fibrosis
534 Succinate dehydrogenase (SDH) inhibition leads to oxidative stress Xavier COUMOUL BY-SA 2118: Succinate dehydrogenase, inhibited 1392: Increase, Oxidative Stress
42 Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals Kevin Crofton BY-SA 279: Thyroperoxidase, Inhibition 402: Cognitive function, decreased WPHA/WNT Endorsed 1.10
33 Kidney toxicity induced by activation of 5HT2C Kevin Crofton Open for adoption 9: Activation, 5HT2c 759: Increased, Kidney Failure
375 test AOP Kevin Crofton BY-SA None None
300 Thyroid Receptor Antagonism and Subsequent Adverse Neurodevelopmental Outcomes in Mammals Kevin Crofton BY-SA 1656: Antagonism, Thyroid Receptor 402: Cognitive function, decreased Under Development 1.84
522 Estrogen antagonism leading to increased risk of autism-like behavior Kanglong Cui Open for adoption 112: Antagonism, Estrogen receptor 2209: autism-like behavior
620 The Adverse Outcome Pathway to Deposition of Energy Leading to Female Decreased Fertility Jessica D'Urbano All rights reserved None None
427 ACE2 downregulation following SARS-CoV-2 infection triggers dysregulation of RAAS and can lead to heart failure. Evangelos-Panagiotis Daskalopoulos BY-SA 1739: Binding to ACE2 1535: Heart failure
426 SARS-CoV-2 spike protein binding to ACE2 receptors expressed on pericytes leads to endothelial cell dysfunction, microvascular injury and myocardial infarction. Evangelos-Panagiotis Daskalopoulos BY-SA 1739: Binding to ACE2 1934: Myocardial Infarction
610 Decreased thyroid hormone levels in the brain regulated via transport, metabolism and TR activation leading to decreased cognition and motor function Nathalie Dierichs All rights reserved
617 The adverse outcome pathway of vascular calcification Ruiyang Ding All rights reserved None None
541 Excessive ROS generation leading to increased incidence of vascular calcification by VSMC phenotype switching Ruiyang Ding BY-SA None None
469 Reactive oxygen speicies overproduction leading to increased digestive morbidity and mortality in generation population Ruiyang Ding BY-SA None None
448 ROS, inflammation, and activation of nAChR lead to increased incidence of cardiovascular morbidity and mortality Ruiyang Ding BY-SA None None
453 Reactive oxygen species and subsequent oxidative stress lead to increased incidence of digestive morbidity and mortality in the general population Ruiyang Ding BY-SA None None
310 Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR Jon Doering BY-SA 18: Activation, AhR
454 PM2.5-related AOP frameworks on liver diseases Zhou Du BY-SA None None
321 Reduced environmental pH leading to thinner shells in Mytilus edulis James Ducker BY-SA None None
131 Aryl hydrocarbon receptor activation leading to uroporphyria Amani Farhat BY-SA 18: Activation, AhR 369: Uroporphyria WPHA/WNT Endorsed 1.7
150 Aryl hydrocarbon receptor activation leading to early life stage mortality, via reduced VEGF Amani Farhat BY-SA 18: Activation, AhR 947: Increase, Early Life Stage Mortality WPHA/WNT Endorsed 1.7
95 Ether-a-go-go (ERG) voltage-gated potassium channel inhibition leading to reduced survival Kellie Fay BY-SA 593: Inhibition, Ether-a-go-go (ERG) voltage-gated potassium channel 592: Reduced, survival
94 Sodium channel inhibition leading to congenital malformations Kellie Fay BY-SA 584: Inhibition, sodium channel 591: Increased, amputations
93 sodium channel inhibition leading to increased predation Kellie Fay BY-SA 584: Inhibition, sodium channel 588: Increased, predation