AOPs

OECD View API
Toggle for API info
The API endpoint defaults to 25 results per page, but you can adjust this by changing the per_page parameter in the URL.
Searches both title and fulltext content
Takes you to the requested AOP
Clear Search Terms Clears search terms and filters

Showing 76 to 100 of 581 AOPs

Clear Table Filters
ID Title Point of Contact License MIE AO OECD Status OECD Project
598 Excessive reactive oxygen species leading to growth inhibition via protein oxidation and reduced cell proliferation You Song BY-SA 1115: Increase, Reactive oxygen species 1521: Decrease, Growth
597 Excessive reactive oxygen species leading to growth inhibition via protein oxidation and reduced cell growth You Song BY-SA None None
587 Inhibition of the mitochondrial complex III of nigro-striatal neurons leads to parkinsonian motor deficits Barbara Viviani BY-SA 1542: Inhibition, Mitochondrial complex III 896: Parkinsonian motor deficits
593 Redox cycling of a chemical by mitochondria leads to degeneration of nigrostriatal dopaminergic neurons Stefan Schildknecht BY-SA 2362: Redox cycling of a chemical by mitochondria 896: Parkinsonian motor deficits
592 DBDPE-induced DNA strand breaks and LDH activity inhibition leading to population growth rate decline via energy metabolism disrupt and apoptosis lihua Yang BY-SA
591 DBDPE-induced DNA damage increase in liver leading to Non-alcoholic fatty liver disease via liver steatosis and inhibition of regeneration lihua Yang BY-SA 1194: Increase, DNA damage 2019: Non-alcoholic fatty liver disease
590 Increase of intracellular copper leading to cuproptosis via interference with energy metabolism Sophie Scholz BY-SA 2339: Intracellular copper, increased 2343: Cuproptosis, increased
589 Inhibition of the mitochondrial complex IV of nigro-striatal neurons leads to parkinsonian motor deficits Barbara Viviani BY-SA 1543: Mitochondrial Complex IV inhibition 896: Parkinsonian motor deficits
588 Inhibition of the mitochondrial complex II of nigro-striatal neurons leads to parkinsonian motor deficits Barbara Viviani BY-SA 2118: Succinate dehydrogenase, inhibited 896: Parkinsonian motor deficits
3 Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits Andrea Terron BY-SA 888: Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I) 896: Parkinsonian motor deficits WPHA/WNT Endorsed 1.33
6 Antagonist binding to PPARα leading to body-weight loss Kurt A. Gust BY-SA 998: Binding of antagonist, PPAR alpha 864: Decreased, Body Weight WPHA/WNT Endorsed 2.3
640 Activation, estrogen receptor alpha leads to decreased fertility via prolonged estrus cycle John Frisch BY-SA 1065: Activation, estrogen receptor alpha 406: decreased, Fertility
641 Activation, estrogen receptor alpha leads to increased, phenotypic female-biased sex ratio via increased, differentiation to ovaries John Frisch BY-SA 1065: Activation, estrogen receptor alpha 2418: Increased, phenotypic female-biased sex ratio
642 Intestinal FXR inhibition leading to steatohepatitis via gut‑liver axis dysregulation Jung-Hwa Oh BY-SA 2421: Inhibition, Intestinal FXR 1489: Increase, Steatohepatitis
627 Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated mitochondrial dysfunction You Song BY-SA 2410: Increase, 11β-Hydroxysteroid dehydrogenase type 1 activity Under Development
628 Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated oxidative stress You Song BY-SA 2410: Increase, 11β-Hydroxysteroid dehydrogenase type 1 activity Under Development
629 Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated endoplasmic reticulum stress You Song BY-SA 2410: Increase, 11β-Hydroxysteroid dehydrogenase type 1 activity Under Development
630 Decreased 11β-Hydroxysteroid dehydrogenase type 2 activity leading to MASLD progression via insulin resistance-associated mitochondrial dysfunction You Song BY-SA 2409: Decrease, 11β-Hydroxysteroid dehydrogenase type 2 activity None Under Development
631 Decreased thyroid hormone receptor beta transcriptional activity leading to MASLD progression via endoplasmic reticulum stress You Song BY-SA None None
632 Increased adrenal glucocorticoid production leading to MASLD progression (3) You Song BY-SA None None
633 Increased adrenal glucocorticoid production leading to MASLD progression (4) You Song BY-SA None None
634 Increased adrenal glucocorticoid production leading to MASLD progression (5) You Song BY-SA None None
635 Increased adrenal glucocorticoid production leading to MASLD progression (6) You Song BY-SA None None
637 Activation, estrogen receptor alpha leads to increased uterine weight via earlier proliferation of cells of the uterine lining John Frisch BY-SA 1065: Activation, estrogen receptor alpha 2413: Increased, uterine weight
638 Co-exposure to microplastics and cadmium leading to progression from NAFLD to liver tumorigenesis Wei Mu BY-SA