AOPs

OECD View API
Toggle for API info
The API endpoint defaults to 25 results per page, but you can adjust this by changing the per_page parameter in the URL.
Searches both title and fulltext content
Takes you to the requested AOP
Clear Search Terms Clears search terms and filters

Showing 76 to 100 of 581 AOPs

Clear Table Filters
ID Title Point of Contact License MIE AO OECD Status OECD Project
96 Axonal sodium channel modulation leading to acute mortality Kellie Fay BY-SA 598: modulation, sodium channel 351: Increased Mortality
97 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline Kellie Fay BY-SA 619: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)
99 Histamine (H2) receptor antagonism leading to reduced survival Kellie Fay BY-SA 638: Antagonism, Histamine Receptor (H2)
100 Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of female spawning behavior Dalma Martinovic-Weigelt BY-SA 79: Inhibition, Cyclooxygenase activity
101 Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of pheromone release Dalma Martinovic-Weigelt BY-SA 79: Inhibition, Cyclooxygenase activity
102 Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition Dalma Martinovic-Weigelt BY-SA 79: Inhibition, Cyclooxygenase activity
103 Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint Dalma Martinovic-Weigelt BY-SA 79: Inhibition, Cyclooxygenase activity
104 Altered ion channel activity leading impaired heart function Undefined BY-SA 697: impaired, ion channels 351: Increased Mortality
105 Alpha2u-microglobulin cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat) Charles Wood BY-SA 714: Increased, Binding of chemicals to 2u (serum) 713: Increase, Adenomas/carcinomas (renal tubular)
108 Inhibition of pyruvate dehydrogenase kinase leading to hepatocellular adenomas and carcinomas (in mouse and rat) Charles Wood BY-SA 724: Inhibition, Pyruvate dehydrogenase kinase (PDK) enzyme 719: Increase, hepatocellular adenomas and carcinomas
71 Modulation of Adult Leydig Cell Function Subsequent to Glucocorticoid Activation Undefined BY-SA 650: Stimulation of adult Leydig cells via the Adrenal Corticosterone, Increased Glucocorticoid 520: Decreased sperm quantity or quality in the adult, Decreased fertility
28 Cyclooxygenase inhibition leading reproductive failure Dan Villeneuve BY-SA 79: Inhibition, Cyclooxygenase activity 253: N/A, Reproductive failure
29 Estrogen receptor agonism leading to reproductive dysfunction Undefined BY-SA 111: Agonism, Estrogen receptor
36 Peroxisomal Fatty Acid Beta-Oxidation Inhibition Leading to Steatosis Michelle Angrish BY-SA 459: Increase, Liver steatosis
52 ER agonism leading to skewed sex ratios due to altered sexual differentiation in males Undefined BY-SA 111: Agonism, Estrogen receptor 417: skewed, sex ratio
53 ER agonism leading to reduced survival due to renal failure Undefined BY-SA 111: Agonism, Estrogen receptor None
57 AhR activation leading to hepatic steatosis Michelle Angrish BY-SA 18: Activation, AhR 459: Increase, Liver steatosis
58 NR1I3 (CAR) suppression leading to hepatic steatosis Michelle Angrish BY-SA 459: Increase, Liver steatosis
59 HNF4alpha suppression leading to hepatic steatosis Michelle Angrish BY-SA 461: Suppression, HNF4alpha None
60 NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis Michelle Angrish BY-SA 245: Activation, PXR/SXR 459: Increase, Liver steatosis
62 AKT2 activation leading to hepatic steatosis Michelle Angrish BY-SA 486: systemic inflammation leading to hepatic steatosis 459: Increase, Liver steatosis
63 Cyclooxygenase inhibition leading to reproductive dysfunction Dalma Martinovic-Weigelt BY-SA 79: Inhibition, Cyclooxygenase activity
64 Glucocorticoid Receptor (GR) Mediated Adult Leydig Cell Dysfunction Leading to Decreased Male Fertility Undefined BY-SA 494: Glucocorticoid Receptor Agonist, Activation 406: decreased, Fertility
66 Modulation of Adult Leydig Cell Function Subsequent Glucocorticoid Activation in the Fetal Testis Undefined BY-SA 505: Decreased sperm quantity / quality in the adult, Decreased fertility
67 Modulation of Adult Leydig Cell Function Subsequent to Estradiaol Activation in the Fetal Testis Undefined BY-SA 505: Decreased sperm quantity / quality in the adult, Decreased fertility